2OBA

Pseudomonas aeruginosa 6-pyruvoyl tetrahydrobiopterin synthase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2obaa1	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
A	d2obaa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
B	d2obab1	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
B	d2obab2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
C	d2obac1	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
C	d2obac2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
D	d2obad1	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
D	d2obad2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
E	d2obae1	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
E	d2obae2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
F	d2obaf1	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	automated matches	automated matches	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)
F	d2obaf2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Pseudomonas aeruginosa ) [TaxId: 287 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	6-pyruvoyl tetrahydropterin synthase	8061623	4001717	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8061624	3000283	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8061624	3000283	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8061624	3000283	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8061624	3000283	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8061624	3000283	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8061624	3000283	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PTPS	e2obaA1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: PTPS	ECOD (1.6)
B	PTPS	e2obaB1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: PTPS	ECOD (1.6)
C	PTPS	e2obaC1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: PTPS	ECOD (1.6)
D	PTPS	e2obaD1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: PTPS	ECOD (1.6)
E	PTPS	e2obaE1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: PTPS	ECOD (1.6)
F	PTPS	e2obaF1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: PTPS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.479.10	Alpha Beta	2-Layer Sandwich	Tetrahydropterin Synthase	Chain A	CATH (4.3.0)
B	3.30.479.10	Alpha Beta	2-Layer Sandwich	Tetrahydropterin Synthase	Chain A	CATH (4.3.0)
C	3.30.479.10	Alpha Beta	2-Layer Sandwich	Tetrahydropterin Synthase	Chain A	CATH (4.3.0)
D	3.30.479.10	Alpha Beta	2-Layer Sandwich	Tetrahydropterin Synthase	Chain A	CATH (4.3.0)
E	3.30.479.10	Alpha Beta	2-Layer Sandwich	Tetrahydropterin Synthase	Chain A	CATH (4.3.0)
F	3.30.479.10	Alpha Beta	2-Layer Sandwich	Tetrahydropterin Synthase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF01242	6-pyruvoyl tetrahydropterin synthase (PTPS)	6-pyruvoyl tetrahydropterin synthase	6-Pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer ...	6-Pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Probable 6-pyruvoyl tetrahydrobiopterin synthase	6-carboxy-5,6,7,8-tetrahydropterin synthase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity cation binding ion binding binding metal ion binding small molecule binding	carbohydrate derivative biosynthetic process glycosyl compound metabolic process glycosyl compound biosynthetic process small molecule biosynthetic process carbohydrate derivative metabolic process primary metabolic process ribonucleoside biosynthetic process nucleoside biosynthetic process nucleobase-containing compound biosynthetic process queuosine metabolic process nucleoside metabolic process nucleobase-containing small molecule biosynthetic process nucleobase-containing compound metabolic process queuosine biosynthetic process biosynthetic process carbohydrate derivative biosynthetic process glycosyl compound metabolic process glycosyl compound biosynthetic process small molecule biosynthetic process carbohydrate derivative metabolic process primary metabolic process ribonucleoside biosynthetic process nucleoside biosynthetic process nucleobase-containing compound biosynthetic process queuosine metabolic process nucleoside metabolic process nucleobase-containing small molecule biosynthetic process nucleobase-containing compound metabolic process queuosine biosynthetic process biosynthetic process nucleobase-containing small molecule metabolic process small molecule metabolic process metabolic process cellular process ribonucleoside metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR038418	6-pyruvoyl tetrahydropterin synthase/QueD superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR007115	6-pyruvoyl tetrahydropterin synthase/QueD family	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.