2ONJ

Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2onja1	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	ABC transporter ATPase domain-like	Putative multidrug export ATP-binding/permease protein SAV1866	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
A	d2onja2	Membrane and cell surface proteins and peptides	ABC transporter transmembrane region	ABC transporter transmembrane region	ABC transporter transmembrane region	Putative multidrug export ATP-binding/permease protein SAV1866	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
B	d2onjb1	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	ABC transporter ATPase domain-like	Putative multidrug export ATP-binding/permease protein SAV1866	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
B	d2onjb2	Membrane and cell surface proteins and peptides	ABC transporter transmembrane region	ABC transporter transmembrane region	ABC transporter transmembrane region	Putative multidrug export ATP-binding/permease protein SAV1866	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ABC transporter transmembrane region-like	8018369	3001546	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8018365	3002020	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ABC transporter transmembrane region-like	8018369	3001546	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8018365	3002020	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ABC_membrane	e2onjA3	A: alpha bundles	X: Type II ABC exporter transmembrane domain fold	H: Type I ABC exporter transmembrane domain fold (From Topology)	T: Type I ABC exporter transmembrane domain fold	F: ABC_membrane	ECOD (1.6)
A	ABC_tran_1	e2onjA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ABC_tran_1	ECOD (1.6)
B	ABC_membrane	e2onjB3	A: alpha bundles	X: Type II ABC exporter transmembrane domain fold	H: Type I ABC exporter transmembrane domain fold (From Topology)	T: Type I ABC exporter transmembrane domain fold	F: ABC_membrane	ECOD (1.6)
B	ABC_tran_1	e2onjB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: ABC_tran_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1560.10	Mainly Alpha	Up-down Bundle	ABC transporter transmembrane region fold	ABC transporter type 1, transmembrane domain	CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	1.20.1560.10	Mainly Alpha	Up-down Bundle	ABC transporter transmembrane region fold	ABC transporter type 1, transmembrane domain	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00664	ABC transporter transmembrane region (ABC_membrane)	ABC transporter transmembrane region	-	Family
A, B	PF00005	ABC transporter (ABC_tran)	ABC transporter	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are comp ...	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Multidrug export ATP-binding/permease protein SAV1866	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ABC-type transporter activity active transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity transporter activity transmembrane transporter activity ATP-dependent activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	-	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036640	ABC transporter type 1, transmembrane domain superfamily	Homologous Superfamily
A, B	IPR003593	AAA+ ATPase domain	Domain
A, B	IPR017871	ABC transporter-like, conserved site	Conserved Site
A, B	IPR011527	ABC transporter type 1, transmembrane domain	Domain
A, B	IPR039421	Type 1 protein exporter	Family
A, B	IPR003439	ABC transporter-like, ATP-binding domain	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	ATP Binding Cassette (ABC) Transporters	Sav1866 Multidrug Transporter in complex with AMP-PNP

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.