2R0D

Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2r0da1	All alpha proteins	alpha-alpha superhelix	Sec7 domain	Sec7 domain	Cytohesin-1/b2-1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d2r0da2	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	Grp1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d2r0da3	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d2r0db1	All alpha proteins	alpha-alpha superhelix	Sec7 domain	Sec7 domain	Cytohesin-1/b2-1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d2r0db2	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	Grp1	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d2r0db3	Artifacts	Tags	Tags	Tags	N-terminal Tags	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Sec7 domain-like	8024146	4001318	SCOP2 (2022-06-29)
A	SCOP2 Family	Pleckstrin-homology domain (PH domain)	8030197	4002395	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Sec7 domain-like	8036525	3001279	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PH domain-like	8042576	3000134	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Sec7 domain-like	8036525	3001279	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PH domain-like	8042576	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PH	e2r0dA2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)
A	Sec7	e2r0dA1	A: alpha arrays	X: Sec7 domain (From Topology)	H: Sec7 domain (From Topology)	T: Sec7 domain	F: Sec7	ECOD (1.6)
B	PH	e2r0dB2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)
B	Sec7	e2r0dB1	A: alpha arrays	X: Sec7 domain (From Topology)	H: Sec7 domain (From Topology)	T: Sec7 domain	F: Sec7	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.220.20	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
A	1.10.1000.11	Mainly Alpha	Orthogonal Bundle	Arf Nucleotide-binding Site Opener	domain 2	CATH (4.3.0)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
B	1.10.220.20	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
B	1.10.1000.11	Mainly Alpha	Orthogonal Bundle	Arf Nucleotide-binding Site Opener	domain 2	CATH (4.3.0)
B	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01369	Sec7 domain (Sec7)	Sec7 domain	The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the Pfam:PF00025 family [2].	Domain
A, B	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Cytohesin-3	GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity binding ion binding phosphatidylinositol-3,4,5-trisphosphate binding anion binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding	regulation of biological process cell adhesion regulation of cellular process positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process cellular process positive regulation of cellular process cellular response to stimulus regulation of signaling small GTPase-mediated signal transduction response to stimulus signaling regulation of biological process cell adhesion regulation of cellular process positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process cellular process positive regulation of cellular process cellular response to stimulus regulation of signaling small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction ARF protein signal transduction regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus regulation of ARF protein signal transduction intracellular signaling cassette regulation of cell communication signal transduction establishment of cell polarity establishment of epithelial cell polarity establishment or maintenance of cell polarity localization transport establishment of localization Golgi vesicle transport vesicle-mediated transport	cell-cell junction adherens junction cellular anatomical structure anchoring junction cell junction ruffle cell projection cell leading edge plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cytosol apical junction complex bicellular tight junction cell-cell junction adherens junction cellular anatomical structure anchoring junction cell junction ruffle cell projection cell leading edge plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cytosol apical junction complex bicellular tight junction tight junction cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001849	Pleckstrin homology domain	Domain
A, B	IPR000904	Sec7 domain	Domain
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B	IPR023394	Sec7, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR035999	Sec7 domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.