Annotations: 2RDY

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Glyco_hyd_65N_2	e2rdyA2	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hyd_65N_2	ECOD (1.6)
A	Glyco_hydro_95_C	e2rdyA3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_95_C	ECOD (1.6)
A	Glyco_hydro_65m	e2rdyA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Glyco_hydro_65m	ECOD (1.6)
B	Glyco_hyd_65N_2	e2rdyB1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hyd_65N_2	ECOD (1.6)
B	Glyco_hydro_95_C	e2rdyB3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_95_C	ECOD (1.6)
B	Glyco_hydro_65m	e2rdyB2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Glyco_hydro_65m	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.70.98.50	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
B	2.70.98.50	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF22124	Glycosyl hydrolase family 95 catalytic domain (Glyco_hydro_95_cat)	Glycosyl hydrolase family 95 catalytic domain	The founding member of the GH95 family of glycosyl hydrolases is alpha-1,2-fucosidase that catalyses the hydrolysis of an alpha-1,2-linked fucose. A member of this family, FucOB from A. muciniphila was shown to hydrolyse all three types of H antigen ...	The founding member of the GH95 family of glycosyl hydrolases is alpha-1,2-fucosidase that catalyses the hydrolysis of an alpha-1,2-linked fucose. A member of this family, FucOB from A. muciniphila was shown to hydrolyse all three types of H antigen structures to obtain the afucosylated Bombay phenotype [6]. Members of this family are multidomain proteins and contain a central catalytic domain with an (alpha/alpha)6 helical barrel topology, represented by this entry.	Domain
A, B	PF21307	Glycoside hydrolase family 95, C-terminal domain (Glyco_hydro_95_C)	Glycoside hydrolase family 95, C-terminal domain	This domain is found in Alpha-fucosidase from Bifidobacterium bifidum (AfcA) and in other members of the glycoside hydrolase family 95 from bacteria and plants. AfcA hydrolyses the glycosidic linkage of Fuc1-2Gal via an inverting mechanism. This entr ...	This domain is found in Alpha-fucosidase from Bifidobacterium bifidum (AfcA) and in other members of the glycoside hydrolase family 95 from bacteria and plants. AfcA hydrolyses the glycosidic linkage of Fuc1-2Gal via an inverting mechanism. This entry represents the C-terminal beta domain present within the catalytic region of this protein. The domain forms a two- layered jelly roll fold. Its specific function remains unknown [1,2].	Domain
A, B	PF14498	Glycosyl hydrolase family 65, N-terminal domain (Glyco_hyd_65N_2)	Glycosyl hydrolase family 65, N-terminal domain	This domain represents a domain found to the N-terminus of the glycosyl hydrolase 65 family catalytic domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	BH0842 protein	fucosidase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds alpha-L-fucosidase activity hydrolase activity catalytic activity	carbohydrate metabolic process primary metabolic process metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR049053	Alpha fucosidase A-like, C-terminal domain	Domain
A, B	IPR016518	Alpha-L-fucosidase	Family
A, B	IPR008928	Six-hairpin glycosidase superfamily	Homologous Superfamily
A, B	IPR027414	Glycosyl hydrolase family 95, N-terminal domain	Domain
A, B	IPR013780	Glycosyl hydrolase, all-beta	Homologous Superfamily
A, B	IPR054363	Glycosyl hydrolase family 95, catalytic domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.