Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyArgK-like 8056301 4003989 SCOP2 (2022-06-29)
ASCOP2 SuperfamilySimibi-like P-loop NTPases 8056302 3002018 SCOP2 (2022-06-29)
DSCOP2B SuperfamilySimibi-like P-loop NTPases 8056302 3002018 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AArgKe2wwwA1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ArgKECOD (1.6)
BArgKe2wwwB1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ArgKECOD (1.6)
CArgKe2wwwC1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ArgKECOD (1.6)
DArgKe2wwwD1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: ArgKECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.20.5.170 Mainly Alpha Up-down Bundle Single alpha-helices involved in coiled-coils or other helix-helix interfaces CATH (4.3.0)
A3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
A1.10.287.130 Mainly Alpha Orthogonal Bundle Helix Hairpins Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domainCATH (4.3.0)
B1.20.5.170 Mainly Alpha Up-down Bundle Single alpha-helices involved in coiled-coils or other helix-helix interfaces CATH (4.3.0)
B3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
B1.10.287.130 Mainly Alpha Orthogonal Bundle Helix Hairpins Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domainCATH (4.3.0)
C1.20.5.170 Mainly Alpha Up-down Bundle Single alpha-helices involved in coiled-coils or other helix-helix interfaces CATH (4.3.0)
C3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
C1.10.287.130 Mainly Alpha Orthogonal Bundle Helix Hairpins Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domainCATH (4.3.0)
D1.20.5.170 Mainly Alpha Up-down Bundle Single alpha-helices involved in coiled-coils or other helix-helix interfaces CATH (4.3.0)
D3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
D1.10.287.130 Mainly Alpha Orthogonal Bundle Helix Hairpins Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF03308Methylmalonyl Co-A mutase-associated GTPase MeaB (MeaB)Methylmalonyl Co-A mutase-associated GTPase MeaBFamily members were previously thought to be ArgK proteins acting as ATPase enzymes and kinases. They are now believed to be methylmalonyl Co-A mutase-associated GTPase MeaB. Structural studies of MeaB and the human ortholog (methylmalonyl associated ...Family members were previously thought to be ArgK proteins acting as ATPase enzymes and kinases. They are now believed to be methylmalonyl Co-A mutase-associated GTPase MeaB. Structural studies of MeaB and the human ortholog (methylmalonyl associated protein A) MMAA, reveal alpha-helical domains at the N- and C-termini as well as a Ras-like GTPase domain. Mutational analysis of MeaB, show prohibited growth in Methylobacterium due to the inability to convert methylmalonyl-CoA to succinyl-CoA caused by an inactive form of methylmalonyl-CoA mutatase (mcm). In humans, mutations in (MMAA) are associated with the fatal disease methylmalonyl aciduria [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL

InterPro: Protein Family Classification InterPro Database Homepage