2J9J
Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor JG-365
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d2j9ja_ | All beta proteins | Acid proteases | Acid proteases | Retroviral protease (retropepsin) | automated matches | (Human immunodeficiency virus 1 ) [TaxId: 11676 ], | SCOPe (2.08) |
B | d2j9jb_ | All beta proteins | Acid proteases | Acid proteases | Retroviral protease (retropepsin) | automated matches | (Human immunodeficiency virus 1 ) [TaxId: 11676 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | RVP | e2j9jA1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: RVP | ECOD (1.6) |
B | RVP | e2j9jB1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: RVP | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
B | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00077 | Retroviral aspartyl protease (RVP) | Retroviral aspartyl protease | Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a ... | Domain | |
PF00077 | Retroviral aspartyl protease (RVP) | Retroviral aspartyl protease | Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a ... | Domain | |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Protein Modification Annotation
Modified Residue(s) | ||
---|---|---|
Chain | Residue(s) | Description |
ABA | Parent Component: ALA :  AA0253 , AA0409 :  S-(2-aminovinyl)-3-methyl-D-cysteine MOD:00258 , L-2-aminobutanoic acid (Glu) MOD:00819 | |
NLE | Parent Component: LEU :  AA0253 , AA0409 | |
SLZ | Parent Component: LYS :  AA0253 , AA0409 | |
ABA | Parent Component: ALA :  AA0253 , AA0409 , AA0253 , AA0409 :  S-(2-aminovinyl)-3-methyl-D-cysteine MOD:00258 , L-2-aminobutanoic acid (Glu) MOD:00819 , S-(2-aminovinyl)-3-methyl-D-cysteine MOD:00258 , L-2-aminobutanoic acid (Glu) MOD:00819 | |
NLE | Parent Component: LEU :  AA0253 , AA0409 , AA0253 , AA0409 | |
SLZ | Parent Component: LYS :  AA0253 , AA0409 , AA0253 , AA0409 | |
ACE | AA0253 , AA0409 , AA0253 , AA0409 , AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 :  S-(2-aminovinyl)-3-methyl-D-cysteine MOD:00258 , L-2-aminobutanoic acid (Glu) MOD:00819 , S-(2-aminovinyl)-3-methyl-D-cysteine MOD:00258 , L-2-aminobutanoic acid (Glu) MOD:00819 , N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359 | :  |
JG3 | AA0253 , AA0409 , AA0253 , AA0409 , AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 | :  |
VME | AA0253 , AA0409 , AA0253 , AA0409 , AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 | :