Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AGTP_EFTU_D2_1e3agqA8 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: GTP_EFTU_D2_1ECOD (1.6)
AGTP_EFTU_D3e3agqA7 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Aminomethyltransferase beta-barrel domainF: GTP_EFTU_D3ECOD (1.6)
AUBA_4e3agqA40 A: alpha arraysX: RuvA-CH: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)T: RuvA-C, UBA, CRAL/TRIO-N, HBS1F: UBA_4ECOD (1.6)
ARNA_replicase_B_2nde3agqA4 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RNA_replicase_B_2ndECOD (1.6)
AEF_TSe3agqA38 A: a+b two layersX: T-foldH: Elongation factor Ts (EF-Ts), dimerisation domain (From Topology)T: Elongation factor Ts (EF-Ts), dimerisation domainF: EF_TSECOD (1.6)
ARNA_replicase_B_1ste3agqA3 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RNA_replicase_B_1stECOD (1.6)
AMnmE_helical_2nde3agqA5 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: MnmE_helical_2ndECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolasesCATH (4.3.0)
A2.40.30.10 Mainly Beta Beta Barrel Elongation Factor Tu (Ef-tu) domain 3CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00009Elongation factor Tu GTP binding domain (GTP_EFTU)Elongation factor Tu GTP binding domainThis domain contains a P-loop motif, also found in several other families such as Pfam:PF00071, Pfam:PF00025 and Pfam:PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.Domain
PF00889Elongation factor TS (EF_TS)Elongation factor TS- Family
PF03143Elongation factor Tu C-terminal domain (GTP_EFTU_D3)Elongation factor Tu C-terminal domainElongation factor Tu consists of three structural domains, this is the third domain. This domain adopts a beta barrel structure. This the third domain is involved in binding to both charged tRNA [1] and binding to EF-Ts Pfam:PF00889 [2].Domain
PF03144Elongation factor Tu domain 2 (GTP_EFTU_D2)Elongation factor Tu domain 2Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA [1]. This domain is also found in other proteins such as e ...Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA [1]. This domain is also found in other proteins such as elongation factor G and translation initiation factor IF-2. This domain is structurally related to Pfam:PF03143, and in fact has weak sequence matches to this domain.
Domain
PF03431RNA replicase, beta-chain (RNA_replicase_B)RNA replicase, beta-chain- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Elongation factor Ts, Elongation factor Tu 1, LINKER, Q beta replicase