3B2V
Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- IMGT Antibody Annotation
- SAbDab Antibody Annotation
- Thera-SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B [auth H] | d3b2vh1 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | V set domains (antibody variable domain-like) | Immunoglobulin heavy chain variable domain, VH | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B [auth H] | d3b2vh2 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | C1 set domains (antibody constant domain-like) | Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B [auth H] | d3b2vh3 | Artifacts | Tags | Tags | Tags | N-terminal Tags | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
C [auth A] | SCOP2B Superfamily | Growth factor receptor domain-like | 8038763 | 3000398 | SCOP2B (2022-06-29) |
C [auth A] | SCOP2B Superfamily | L domain-like | 8038760 | 3001010 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth L] | C1-set_4 | e3b2vL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_4 | ECOD (1.6) |
A [auth L] | V-set | e3b2vL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set | ECOD (1.6) |
B [auth H] | V-set_8 | e3b2vH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
B [auth H] | C1-set_1 | e3b2vH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
C [auth A] | Recep_L_domain | e3b2vA2 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: Recep_L_domain | ECOD (1.6) |
C [auth A] | GF_recep_IV | e3b2vA3 | A: few secondary structure elements | X: EGF-like | H: Growth factor receptor domain (From Topology) | T: Growth factor receptor domain | F: GF_recep_IV | ECOD (1.6) |
C [auth A] | Furin-like_4 | e3b2vA1 | A: few secondary structure elements | X: EGF-like | H: Growth factor receptor domain (From Topology) | T: Growth factor receptor domain | F: Furin-like_4 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
B [auth H] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
C [auth A] | 2.10.220.10 | Mainly Beta | Ribbon | Hormone Receptor, Insulin-like Growth Factor Receptor 1 | Chain A domain 2 | CATH (4.3.0) |
C [auth A] | 3.80.20.20 | Alpha Beta | Alpha-Beta Horseshoe | 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a' | Chain A | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
A [auth L] | IMC-11F8 Fab, anti-EGFR | L-KAPPA | Homo sapiens (human) | IGKV3D-11*01, IGKJ4*01, IGKJ4*02, IGKC*01 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-1_KAPPA | IMGT (202443-0) |
B [auth H] | IMC-11F8 Fab, anti-EGFR | VH-CH1 | Homo sapiens (human) | IGHV4-30-4*01, IGHJ4*01, IGHJ4*02, IGHJ4*03, IGHG1*01, IGHG1*02, IGHG1*04 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_KAPPA | IMGT (202443-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
A [auth L] | Light Chain | IGKV3 | Kappa | epidermal growth factor receptor | SAbDab (2024-11-01) |
B [auth H] | Heavy Chain | IGHV4 | - | epidermal growth factor receptor | SAbDab (2024-11-01) |
Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage
Chain | Name | Target | Provenance Source |
---|---|---|---|
A [auth L] | Necitumumab | EGFR/ERBB1/HER1 | Therapeutic SAbDab (2024-11-01) |
B [auth H] | Necitumumab | EGFR/ERBB1/HER1 | Therapeutic SAbDab (2024-11-01) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
B [auth H] | PF07686 | Immunoglobulin V-set domain (V-set) | Immunoglobulin V-set domain | This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others. | Domain |
B [auth H] | PF07654 | Immunoglobulin C1-set domain (C1-set) | Immunoglobulin C1-set domain | - | Domain |
C [auth A] | PF01030 | Receptor L domain (Recep_L_domain) | Receptor L domain | - | Repeat |
C [auth A] | PF14843 | Growth factor receptor domain IV (GF_recep_IV) | Growth factor receptor domain IV | This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (Pfam:PF00757) regulates the binding of ligands to the receptor L domains (Pfam:PF01030) [1]. | Domain |