Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
C [auth A]SCOP2B SuperfamilyGrowth factor receptor domain-like 8038763 3000398 SCOP2B (2022-06-29)
C [auth A]SCOP2B SuperfamilyL domain-like 8038760 3001010 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth L]C1-set_4e3b2vL2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
A [auth L]V-sete3b2vL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
B [auth H]V-set_8e3b2vH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
B [auth H]C1-set_1e3b2vH2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
C [auth A]Recep_L_domaine3b2vA2 A: beta duplicates or obligate multimersX: Single-stranded right-handed beta-helixH: Leucine-rich repeats (From Topology)T: Leucine-rich repeatsF: Recep_L_domainECOD (1.6)
C [auth A]GF_recep_IVe3b2vA3 A: few secondary structure elementsX: EGF-likeH: Growth factor receptor domain (From Topology)T: Growth factor receptor domainF: GF_recep_IVECOD (1.6)
C [auth A]Furin-like_4e3b2vA1 A: few secondary structure elementsX: EGF-likeH: Growth factor receptor domain (From Topology)T: Growth factor receptor domainF: Furin-like_4ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
A [auth L]IMC-11F8 Fab, anti-EGFR L-KAPPA Homo sapiens (human) IGKV3D-11*01, IGKJ4*01, IGKJ4*02, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202443-0)
B [auth H]IMC-11F8 Fab, anti-EGFR VH-CH1 Homo sapiens (human) IGHV4-30-4*01, IGHJ4*01, IGHJ4*02, IGHJ4*03, IGHG1*01, IGHG1*02, IGHG1*04 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202443-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
A [auth L]Light ChainIGKV3 Kappaepidermal growth factor receptorSAbDab (2024-11-01)
B [auth H]Heavy ChainIGHV4 -epidermal growth factor receptorSAbDab (2024-11-01)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

ChainNameTargetProvenance Source
A [auth L] Necitumumab EGFR/ERBB1/HER1Therapeutic SAbDab (2024-11-01)
B [auth H] Necitumumab EGFR/ERBB1/HER1Therapeutic SAbDab (2024-11-01)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B [auth H]PF07686Immunoglobulin V-set domain (V-set)Immunoglobulin V-set domainThis domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.Domain
B [auth H]PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
C [auth A]PF01030Receptor L domain (Recep_L_domain)Receptor L domain- Repeat
C [auth A]PF14843Growth factor receptor domain IV (GF_recep_IV)Growth factor receptor domain IVThis is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (Pfam:PF00757) regulates the binding of ligands to the receptor L domains (Pfam:PF01030) [1].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth L]IMC-11F8 FAB Light chain---
B [auth H]IMC-11F8 FAB Heavy chain-
C [auth A]Epidermal growth factor receptor

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
B [auth H]IPR003597Immunoglobulin C1-setDomain
B [auth H]IPR013783Immunoglobulin-like foldHomologous Superfamily
B [auth H]IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
B [auth H]IPR013106Immunoglobulin V-set domainDomain
B [auth H]IPR003599Immunoglobulin domain subtypeDomain
B [auth H]IPR007110Immunoglobulin-like domainDomain
B [auth H]IPR050380Immune Recognition and Response ModulatorsFamily
B [auth H]IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site
C [auth A]IPR016245Tyrosine protein kinase, EGF/ERB/XmrK receptorFamily
C [auth A]IPR020635Tyrosine-protein kinase, catalytic domainDomain
C [auth A]IPR000719Protein kinase domainDomain
C [auth A]IPR032778Growth factor receptor domain 4Domain
C [auth A]IPR006212Furin-like repeatRepeat
C [auth A]IPR017441Protein kinase, ATP binding siteBinding Site
C [auth A]IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainDomain
C [auth A]IPR009030Growth factor receptor cysteine-rich domain superfamilyHomologous Superfamily
C [auth A]IPR008266Tyrosine-protein kinase, active siteActive Site
C [auth A]IPR036941Receptor L-domain superfamilyHomologous Superfamily
C [auth A]IPR049328Epidermal growth factor receptor-like, transmembrane-juxtamembrane segmentDomain
C [auth A]IPR000494Receptor L-domainDomain
C [auth A]IPR011009Protein kinase-like domain superfamilyHomologous Superfamily
C [auth A]IPR006211Furin-like cysteine-rich domainDomain
C [auth A]IPR050122Receptor Tyrosine KinaseFamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
C [auth A]PharosP00533