Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APYC_OADA_2nde3bg3A2 A: alpha arraysX: RuvA-CH: post-HMGL domain-like (From Topology)T: post-HMGL domain-likeF: PYC_OADA_2ndECOD (1.6)
APYC_OADA_1ste3bg3A4 A: alpha arraysX: RuvA-CH: post-HMGL domain-like (From Topology)T: post-HMGL domain-likeF: PYC_OADA_1stECOD (1.6)
APYC_OADA_3rde3bg3A5 A: a+b two layersX: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related (From Homology)H: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-relatedT: a+b domain in pyruvate carboxylaseF: PYC_OADA_3rdECOD (1.6)
ABiotin_lipoyle3bg3A1 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: Biotin_lipoylECOD (1.6)
AHMGL-like_2e3bg3A3 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: HMGL-like_2ECOD (1.6)
BPYC_OADA_2nde3bg3B7 A: alpha arraysX: RuvA-CH: post-HMGL domain-like (From Topology)T: post-HMGL domain-likeF: PYC_OADA_2ndECOD (1.6)
BPYC_OADA_1ste3bg3B9 A: alpha arraysX: RuvA-CH: post-HMGL domain-like (From Topology)T: post-HMGL domain-likeF: PYC_OADA_1stECOD (1.6)
BPYC_OADA_3rde3bg3B10 A: a+b two layersX: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related (From Homology)H: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-relatedT: a+b domain in pyruvate carboxylaseF: PYC_OADA_3rdECOD (1.6)
BHMGL-like_2e3bg3B8 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: HMGL-like_2ECOD (1.6)
CPYC_OADA_2nde3bg3C7 A: alpha arraysX: RuvA-CH: post-HMGL domain-like (From Topology)T: post-HMGL domain-likeF: PYC_OADA_2ndECOD (1.6)
CPYC_OADA_1ste3bg3C9 A: alpha arraysX: RuvA-CH: post-HMGL domain-like (From Topology)T: post-HMGL domain-likeF: PYC_OADA_1stECOD (1.6)
CPYC_OADA_3rde3bg3C10 A: a+b two layersX: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related (From Homology)H: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-relatedT: a+b domain in pyruvate carboxylaseF: PYC_OADA_3rdECOD (1.6)
CHMGL-like_2e3bg3C8 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: HMGL-like_2ECOD (1.6)
DPYC_OADA_2nde3bg3D6 A: alpha arraysX: RuvA-CH: post-HMGL domain-like (From Topology)T: post-HMGL domain-likeF: PYC_OADA_2ndECOD (1.6)
DPYC_OADA_1ste3bg3D1 A: alpha arraysX: RuvA-CH: post-HMGL domain-like (From Topology)T: post-HMGL domain-likeF: PYC_OADA_1stECOD (1.6)
DPYC_OADA_3rde3bg3D5 A: a+b two layersX: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-related (From Homology)H: Methylcrotonyl-CoA carboxylase alpha-subunit BT domain-relatedT: a+b domain in pyruvate carboxylaseF: PYC_OADA_3rdECOD (1.6)
DBiotin_lipoyle3bg3D4 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Single hybrid motifF: Biotin_lipoylECOD (1.6)
DHMGL-like_2e3bg3D7 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: HMGL-like_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.10.600.10 Alpha Beta Roll pyruvate carboxylase f1077a mutant fold pyruvate carboxylase f1077a mutant domainCATH (4.3.0)
A3.20.20.70 Alpha Beta Alpha-Beta Barrel TIM Barrel Aldolase class ICATH (4.3.0)
A1.10.472.90 Mainly Alpha Orthogonal Bundle Cyclin A domain 1CATH (4.3.0)
A1.10.10.60 Mainly Alpha Orthogonal Bundle Arc Repressor Mutant, subunit A Homeodomain-likeCATH (4.3.0)
A2.40.50.100 Mainly Beta Beta Barrel OB fold (Dihydrolipoamide Acetyltransferase, E2P) RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domainCATH (4.3.0)
B3.10.600.10 Alpha Beta Roll pyruvate carboxylase f1077a mutant fold pyruvate carboxylase f1077a mutant domainCATH (4.3.0)
B3.20.20.70 Alpha Beta Alpha-Beta Barrel TIM Barrel Aldolase class ICATH (4.3.0)
B1.10.472.90 Mainly Alpha Orthogonal Bundle Cyclin A domain 1CATH (4.3.0)
B1.10.10.60 Mainly Alpha Orthogonal Bundle Arc Repressor Mutant, subunit A Homeodomain-likeCATH (4.3.0)
C3.10.600.10 Alpha Beta Roll pyruvate carboxylase f1077a mutant fold pyruvate carboxylase f1077a mutant domainCATH (4.3.0)
C3.20.20.70 Alpha Beta Alpha-Beta Barrel TIM Barrel Aldolase class ICATH (4.3.0)
C1.10.472.90 Mainly Alpha Orthogonal Bundle Cyclin A domain 1CATH (4.3.0)
C1.10.10.60 Mainly Alpha Orthogonal Bundle Arc Repressor Mutant, subunit A Homeodomain-likeCATH (4.3.0)
D3.20.20.70 Alpha Beta Alpha-Beta Barrel TIM Barrel Aldolase class ICATH (4.3.0)
D1.10.472.90 Mainly Alpha Orthogonal Bundle Cyclin A domain 1CATH (4.3.0)
D1.10.10.60 Mainly Alpha Orthogonal Bundle Arc Repressor Mutant, subunit A Homeodomain-likeCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF00682HMGL-like (HMGL-like)HMGL-likeThis family contains a diverse set of enzymes. These include various aldolases and a region of pyruvate carboxylase.Domain
A, B, C, D
PF00364Biotin-requiring enzyme (Biotin_lipoyl)Biotin-requiring enzymeThis family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognise the Glycine cleavage system H proteins.Domain
A, B, C, D
PF02436Conserved carboxylase domain (PYC_OADA)Conserved carboxylase domainThis domain represents a conserved region in pyruvate carboxylase (PYC), oxaloacetate decarboxylase alpha chain (OADA), and transcarboxylase 5s subunit. The domain is found adjacent to the HMGL-like domain (Pfam:PF00682) and often close to the bio ...This domain represents a conserved region in pyruvate carboxylase (PYC), oxaloacetate decarboxylase alpha chain (OADA), and transcarboxylase 5s subunit. The domain is found adjacent to the HMGL-like domain (Pfam:PF00682) and often close to the biotin_lipoyl domain (Pfam:PF00364) of biotin requiring enzymes.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
Pyruvate carboxylase, mitochondrial