Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyFamilies 57/38 glycoside transferase middle domain 8039561 3000997 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyGalactose mutarotase-like 8039564 3000035 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyGlycoside hydrolase/deacetylase 8039566 3001025 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AKOG1958e3bubA6 A: beta sandwichesX: Glycosyl hydrolase domain-likeH: Glycosyl hydrolase domain (From Topology)T: Glycosyl hydrolase domainF: KOG1958ECOD (1.6)
AKOG1959e3bubA5 A: beta sandwichesX: Glycosyl hydrolase domain-likeH: Glycosyl hydrolase domain (From Topology)T: Glycosyl hydrolase domainF: KOG1959ECOD (1.6)
AGlyco_hydro_38C_1st_1e3bubA4 A: beta sandwichesX: Glycosyl hydrolase domain-likeH: supersandwich (From Topology)T: supersandwichF: Glyco_hydro_38C_1st_1ECOD (1.6)
AAlpha-mann_mide3bubA2 A: alpha bundlesX: immunoglobulin/albumin-binding domain-likeH: Families 57/38 glycoside transferase middle domain (From Topology)T: Families 57/38 glycoside transferase middle domainF: Alpha-mann_midECOD (1.6)
AGlyco_hydro_38e3bubA3 A: a/b barrelsX: TIM beta/alpha-barrelH: Glycoside hydrolase/deacetylase (From Topology)T: Glycoside hydrolase/deacetylaseF: Glyco_hydro_38ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF18230Glycosyl hydrolases family 38 C-terminal sub-domain (Glyc_hyd_38C_2)Glycosyl hydrolases family 38 C-terminal sub-domainThis is a subdomain found in the C-terminal region of golgi alpha-mannosidase II present in Drosophila melanogaster. These proteins are important in glycoprotein processing and are thought to cleave mannosidic bonds through a double displacement mech ...This is a subdomain found in the C-terminal region of golgi alpha-mannosidase II present in Drosophila melanogaster. These proteins are important in glycoprotein processing and are thought to cleave mannosidic bonds through a double displacement mechanism involving a reaction intermediate.This subdomain is found at the C-terminal of Glycosyl hydrolases family 38 C-terminal domain [1].
Domain
PF01074Glycosyl hydrolases family 38 N-terminal domain (Glyco_hydro_38N)Glycosyl hydrolases family 38 N-terminal domainGlycosyl hydrolases are key enzymes of carbohydrate metabolism.Domain
PF09261Alpha mannosidase middle domain (Alpha-mann_mid)Alpha mannosidase middle domainMembers of this family adopt a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. They are predominantly found in the enzyme alpha-mannosidase [1].Domain
PF21260Lysosomal alpha-mannosidase-like, central domain (Laman-like_dom)Lysosomal alpha-mannosidase-like, central domainThis domain is found in Lysosomal alpha-mannosidase from Bos taurus (Laman) and similar proteins from eukaryotes. This protein is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Laman, which belongs to th ...This domain is found in Lysosomal alpha-mannosidase from Bos taurus (Laman) and similar proteins from eukaryotes. This protein is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Laman, which belongs to the glycoside hydrolase family 38 (GH38), is organised into four domains: the alpha-beta N-terminal Pfam:PF01074, a three-helix bundle domain Pfam:PF09261, and three mainly beta-sheet domains (covered by this entry, Pfam:PF07748 and Pfam:PF17677) [1-5].
Domain
PF07748Glycosyl hydrolases family 38 C-terminal domain (Glyco_hydro_38C)Glycosyl hydrolases family 38 C-terminal domainGlycosyl hydrolases are key enzymes of carbohydrate metabolism.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Alpha-mannosidase 2