Annotations: 3F2B

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	tRNA_anti-codon_1	e3f2bA7	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: tRNA_anti-codon_1	ECOD (1.6)
A	HHH_6	e3f2bA5	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: HHH_6	ECOD (1.6)
A	DNA_pol3_alpha_C	e3f2bA4	A: alpha arrays	X: DNA polymerase III finger domain (From Topology)	H: DNA polymerase III finger domain (From Topology)	T: DNA polymerase III finger domain	F: DNA_pol3_alpha_C	ECOD (1.6)
A	DNA_pol3_alpha_N	e3f2bA1	A: a+b three layers	X: Nucleotidyltransferase-like	H: Nucleotidyltransferase (From Topology)	T: Nucleotidyltransferase	F: DNA_pol3_alpha_N	ECOD (1.6)
A	PHP	e3f2bA2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PHP	ECOD (1.6)
A	polC	e3f2bA6	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: polC	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
A	3.20.20.140	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Metal-dependent hydrolases	CATH (4.3.0)
A	3.30.1900.20	Alpha Beta	2-Layer Sandwich	glyoxalase-related enzyme like fold		CATH (4.3.0)
A	6.10.50.10	Special	Helix non-globular	Insulin-like, subunit E		CATH (4.3.0)
A	1.10.150.700	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
A	6.10.140.1510	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
A	1.10.150.870	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02811	PHP domain (PHP)	PHP domain	-	Family
A	PF07733	Bacterial DNA polymerase III alpha NTPase domain (DNA_pol3_alpha)	Bacterial DNA polymerase III alpha NTPase domain	-	Domain
A	PF14579	Helix-hairpin-helix motif (HHH_6)	Helix-hairpin-helix motif	The HHH domain is a short DNA-binding domain [1].	Domain
A	PF01336	OB-fold nucleic acid binding domain (tRNA_anti-codon)	OB-fold nucleic acid binding domain	This family contains OB-fold domains that bind to nucleic acids [4]. The family includes the anti-codon binding domain of lysyl, aspartyl, and asparaginyl -tRNA synthetases (See Pfam:PF00152). Aminoacyl-tRNA synthetases catalyse the addition of an a ...	This family contains OB-fold domains that bind to nucleic acids [4]. The family includes the anti-codon binding domain of lysyl, aspartyl, and asparaginyl -tRNA synthetases (See Pfam:PF00152). Aminoacyl-tRNA synthetases catalyse the addition of an amino acid to the appropriate tRNA molecule EC:6.1.1.-. This family also includes part of RecG helicase involved in DNA repair. Replication factor A is a hetero-trimeric complex, that contains a subunit in this family [2,3]. This domain is also found at the C-terminus of bacterial DNA polymerase III alpha chain.	Domain
A	PF17657	Bacterial DNA polymerase III alpha subunit finger domain (DNA_pol3_finger)	Bacterial DNA polymerase III alpha subunit finger domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA-directed DNA polymerase III alpha chain	catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups DNA binding binding organic cyclic compound binding nucleic acid binding nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups DNA binding binding organic cyclic compound binding nucleic acid binding nuclease activity hydrolase activity, acting on ester bonds 3'-5' exonuclease activity hydrolase activity exonuclease activity cation binding ion binding metal ion binding small molecule binding	nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm
B [auth P]	5'-D(DCPDAPDGPDTPDGPDAPDGPDAPDCPDGPDGPDGPDCPDAPDAPDCP*DC)-3'	-	-	-
C [auth T]	5'-D(DAPDTPDAPDAPDCPDGPDGPDTPDTPDGPDCPDCPDCPDGPDTPDCPDTPDCPDAPDCPDTPDG)-3'	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
A	IPR006054	DNA polymerase III epsilon subunit, exonuclease domain	Domain
A	IPR040982	DNA polymerase III alpha subunit finger domain	Domain
A	IPR004013	PHP domain	Domain
A	IPR024754	DNA polymerase III PolC-like, N-terminal domain II	Domain
A	IPR028112	DNA polymerase III PolC-type, N-terminal domain I	Domain
A	IPR006308	DNA polymerase III, alpha subunit, PolC-type, Gram-positive bacteria	Family
A	IPR004365	OB-fold nucleic acid binding domain, AA-tRNA synthetase-type	Domain
A	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A	IPR003141	Polymerase/histidinol phosphatase, N-terminal	Domain
A	IPR011708	Bacterial DNA polymerase III, alpha subunit, NTPase domain	Domain
A	IPR029460	DNA polymerase, helix-hairpin-helix motif	Domain
A	IPR004805	Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC	Family
A	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
A	IPR013520	Exonuclease, RNase T/DNA polymerase III	Domain
A	IPR044923	PolC, middle finger subdomain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.