3SC0

Crystal Structure of MMACHC (1-238), a human B12 processing enzyme, complexed with MethylCobalamin

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CblC-like	8045993	4004808	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	FMN-dependent nitroreductase-like	8092562	3001947	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MMACHC	e3sc0A1	A: a+b two layers	X: Alpha-beta plaits	H: FMN-dependent nitroreductase-like (From Topology)	T: FMN-dependent nitroreductase-like	F: MMACHC	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16690	Methylmalonic aciduria and homocystinuria type C family (MMACHC)	Methylmalonic aciduria and homocystinuria type C family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Methylmalonic aciduria and homocystinuria type C protein	oxidoreductase activity catalytic activity demethylase activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity oxidoreductase activity, acting on metal ions oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity FAD binding flavin adenine dinucleotide binding nucleoside phosphate binding oxidoreductase activity catalytic activity demethylase activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity oxidoreductase activity, acting on metal ions oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity FAD binding flavin adenine dinucleotide binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding amide binding modified amino acid binding oligopeptide binding glutathione binding sulfur compound binding vitamin binding cobalamin binding tetrapyrrole binding transferase activity	cobalamin metabolic process tetrapyrrole metabolic process small molecule metabolic process metabolic process cellular process water-soluble vitamin metabolic process vitamin metabolic process demethylation glutathione metabolic process modified amino acid metabolic process sulfur compound metabolic process amide metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032037	Methylmalonic aciduria and homocystinuria type C family	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y4U1	methylmalonic acidemia with homocystinuria methylmalonic aciduria and homocystinuria type cblC Ataxias, Hereditary methylmalonic acidemia ovarian cancer benign concentric annular macular dystrophy homocystinuria intellectual disability pancreatic ductal adenocarcinoma chronic obstructive pulmonary disease hydrocephalus lung cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.