4AXG

Structure of eIF4E-Cup complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4axga_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
B	d4axgb_	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Translation initiation factor eIF4e	8072935	4001578	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	eIF4e-like	8072936	3001871	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	eIF4e-like	8072936	3001871	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IF4E	e4axgA1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: IF4E	ECOD (1.6)
B	IF4E	e4axgB1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: IF4E	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)
B	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01652	Eukaryotic initiation factor 4E (IF4E)	Eukaryotic initiation factor 4E	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding protein binding translation initiation factor binding eukaryotic initiation factor 4G binding RNA binding RNA 7-methylguanosine cap binding RNA cap binding	cellular biosynthetic process cellular metabolic process primary metabolic process translation gene expression macromolecule biosynthetic process biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process nucleobase-containing compound metabolic process RNA metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process translation gene expression macromolecule biosynthetic process biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process nucleobase-containing compound metabolic process RNA metabolic process nucleic acid metabolic process	neuromuscular junction synapse cell junction cellular anatomical entity neuron projection cytoplasm intracellular anatomical structure cytoplasmic ribonucleoprotein granule neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection ribonucleoprotein granule intracellular organelle cell projection neuromuscular junction synapse cell junction cellular anatomical entity neuron projection cytoplasm intracellular anatomical structure cytoplasmic ribonucleoprotein granule neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection ribonucleoprotein granule intracellular organelle cell projection organelle neuronal ribonucleoprotein granule intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle muscle cell postsynaptic specialization postsynapse postsynaptic specialization postsynapse of neuromuscular junction cytosol P-body protein-containing complex eukaryotic translation initiation factor 4F complex RNA cap binding complex intracellular protein-containing complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
C, D	PROTEIN CUP	translation regulator activity eukaryotic initiation factor 4E binding protein binding binding translation initiation factor binding RNA binding organic cyclic compound binding nucleic acid binding mRNA binding	regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process developmental process sexual reproduction cellular developmental process reproductive process oogenesis multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism female gamete generation developmental process involved in reproduction gamete generation cell differentiation anatomical structure development germ cell development dorsal/ventral pattern formation multicellular organism development multicellular organismal process pattern specification process regionalization organelle fission meiotic cell cycle meiotic cell cycle process cellular component organization nuclear division organelle organization female meiotic nuclear division meiotic nuclear division cellular component organization or biogenesis cell cycle cell cycle process regulation of cellular component organization negative regulation of cellular component organization protein-containing complex organization eukaryotic translation initiation factor 4F complex assembly regulation of cellular component biogenesis regulation of eukaryotic translation initiation factor 4F complex assembly negative regulation of protein-containing complex assembly cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly negative regulation of eukaryotic translation initiation factor 4F complex assembly protein-containing complex assembly negative regulation of oskar mRNA translation regulation of oskar mRNA translation localization cellular localization cellular macromolecule localization macromolecule localization intracellular mRNA localization RNA localization translational initiation regulation of translational initiation negative regulation of translational initiation meiotic chromosome segregation nuclear chromosome segregation chromosome segregation regulation of growth regulation of developmental process developmental growth neuromuscular junction development cell junction assembly regulation of synaptic assembly at neuromuscular junction regulation of synapse structure or activity synapse organization regulation of biological quality regulation of synapse assembly regulation of neuromuscular junction development system development regulation of developmental growth growth nervous system development regulation of cell junction assembly regulation of synapse organization cell junction organization synaptic assembly at neuromuscular junction synapse assembly epithelial cell differentiation follicle cell of egg chamber development tissue migration ameboidal-type cell migration epithelial cell migration cell migration cell motility epithelium development follicle cell of egg chamber migration tissue development epithelium migration epithelial cell development regulation of localization blastoderm segmentation anterior/posterior pattern specification anterior/posterior axis specification, embryo pole plasm oskar mRNA localization oocyte development cell maturation pole plasm mRNA localization pole plasm RNA localization embryonic pattern specification regulation of intracellular mRNA localization oocyte anterior/posterior axis specification developmental maturation cytoplasm organization anatomical structure maturation maternal determination of anterior/posterior axis, embryo intracellular mRNA localization involved in anterior/posterior axis specification axis specification segmentation embryo development tripartite regional subdivision embryonic axis specification regulation of pole plasm oskar mRNA localization anterior/posterior axis specification oocyte axis specification oocyte construction pole plasm assembly regulation of cellular localization intracellular mRNA localization involved in pattern specification process oocyte differentiation cell growth oocyte growth in germarium-derived egg chamber growth of a germarium-derived egg chamber developmental cell growth oocyte growth	axon synapse neuron projection cellular anatomical entity axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon terminal bouton cell junction neuron projection terminus intracellular anatomical structure cytoplasm axon synapse neuron projection cellular anatomical entity axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon terminal bouton cell junction neuron projection terminus intracellular anatomical structure cytoplasm cytosol neuromuscular junction neuron projection cytoplasm cytoplasmic ribonucleoprotein granule cytoplasmic region plasma membrane bounded cell projection cytoplasm ribonucleoprotein granule intracellular organelle organelle neuronal ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex non-membrane-bounded organelle P-body membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR019770	Eukaryotic translation initiation factor 4E (eIF-4E), conserved site	Conserved Site
A, B	IPR023398	Translation Initiation factor eIF- 4e-like	Homologous Superfamily
A, B	IPR001040	Translation Initiation factor eIF- 4e	Family
C, D	IPR018862	Eukaryotic translation initiation factor 4E binding protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.