4BPM

Crystal structure of a human integral membrane enzyme

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	MAPEG domain	8073546	4002741	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	MAPEG domain-like	8073547	3001687	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MAPEG	e4bpmA1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: MAPEG domain-like (From Topology)	T: MAPEG domain-like	F: MAPEG	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.550	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Membrane associated eicosanoid/glutathione metabolism-like domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01124	MAPEG family (MAPEG)	MAPEG family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROSTAGLANDIN E SYNTHASE, FUSION PEPTIDE	amide binding modified amino acid binding binding ion binding oligopeptide binding anion binding glutathione binding sulfur compound binding small molecule binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor glutathione peroxidase activity amide binding modified amino acid binding binding ion binding oligopeptide binding anion binding glutathione binding sulfur compound binding small molecule binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor glutathione peroxidase activity catalytic activity glutathione transferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups isomerase activity intramolecular oxidoreductase activity prostaglandin-D synthase activity prostaglandin-E synthase activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity lipid binding carbon-sulfur lyase activity leukotriene-C4 synthase activity lyase activity identical protein binding protein binding	acute-phase response multicellular organismal process regulation of defense response regulation of heat generation response to stimulus regulation of response to external stimulus homeostatic process heat generation response to stress regulation of response to stress regulation of multicellular organismal process acute inflammatory response fever generation regulation of biological process acute-phase response multicellular organismal process regulation of defense response regulation of heat generation response to stimulus regulation of response to external stimulus homeostatic process heat generation response to stress regulation of response to stress regulation of multicellular organismal process acute inflammatory response fever generation regulation of biological process defense response biological regulation regulation of inflammatory response response to external stimulus multicellular organismal-level homeostasis regulation of response to stimulus temperature homeostasis regulation of fever generation regulation of acute inflammatory response inflammatory response negative regulation of cell population proliferation cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process cellular process icosanoid metabolic process prostaglandin metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process cellular biosynthetic process lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process prostanoid metabolic process icosanoid biosynthetic process small molecule metabolic process prostaglandin biosynthetic process prostanoid biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process primary metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process biosynthetic process cellular lipid metabolic process metabolic process monocarboxylic acid metabolic process lipid metabolic process regulation of localization cell communication localization regulation of prostaglandin secretion monocarboxylic acid transport fatty acid transport prostaglandin secretion positive regulation of icosanoid secretion carboxylic acid transport lipid transport establishment of localization regulation of fatty acid transport regulation of secretion organic acid transport positive regulation of lipid transport lipid export from cell prostaglandin transport transport signaling positive regulation of biological process regulation of lipid transport positive regulation of secretion by cell regulation of secretion by cell secretion by cell positive regulation of secretion icosanoid transport signal release regulation of icosanoid secretion positive regulation of prostaglandin secretion icosanoid secretion positive regulation of cellular process organic anion transport regulation of transport secretion export from cell cell-cell signaling lipid localization positive regulation of lipid localization positive regulation of organic acid transport positive regulation of transport regulation of lipid localization macromolecule localization regulation of organic acid transport positive regulation of fatty acid transport system process sensory perception nervous system process sensory perception of pain cellular response to stimulus signal transduction leukotriene metabolic process leukotriene biosynthetic process long-chain fatty acid metabolic process long-chain fatty acid biosynthetic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope organelle lumen organelle nuclear envelope lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope organelle lumen organelle nuclear envelope lumen nuclear envelope membrane perinuclear region of cytoplasm cytoplasm organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane nuclear outer membrane nuclear membrane organelle outer membrane bounding membrane of organelle outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001129	Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein	Family
A	IPR023352	Membrane associated eicosanoid/glutathione metabolism-like domain superfamily	Homologous Superfamily
A	IPR040162	Microsomal glutathione S-transferase 1-like	Family
A	IPR001129	Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein	Family
A	IPR050997	Membrane-associated proteins in eicosanoid and glutathione metabolism	Family
A	IPR018295	FLAP/GST2/LTC4S, conserved site	Conserved Site
A	IPR023352	Membrane associated eicosanoid/glutathione metabolism-like domain superfamily	Homologous Superfamily
A	IPR001446	5-lipoxygenase-activating protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q16873	Fever hydronephrosis rheumatoid arthritis intrinsic asthma malignant mesothelioma ovarian cancer prostate carcinoma tuberculosis allergic asthma Crohn ileitis invasive ductal breast carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis ulcerative colitis Fever hydronephrosis rheumatoid arthritis intrinsic asthma malignant mesothelioma ovarian cancer prostate carcinoma tuberculosis allergic asthma Crohn ileitis invasive ductal breast carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis ulcerative colitis ankylosing spondylitis juvenile idiopathic arthritis osteoarthritis hypotonia-failure to thrive-microcephaly syndrome Asthma, Aspirin-Induced drug allergy

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Alpha-helical polytopic	MAPEG (Eicosanoid and Glutathione metabolism proteins)	MAPEG family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.