Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042116 3001728 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042116 3001728 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ASIR2_1ste4bv2A1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: SIR2_1stECOD (1.6)
ASIR2_2nd_1e4bv2A2 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Rubredoxin-relatedF: SIR2_2nd_1ECOD (1.6)
BSIR2_1ste4bv2B2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: SIR2_1stECOD (1.6)
BSIR2_2nd_2e4bv2B3 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Rubredoxin-relatedF: SIR2_2nd_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.1220 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold TPP-binding domainCATH (4.3.0)
A3.30.1600.10 Alpha Beta 2-Layer Sandwich SIR2/SIRT2 'Small Domain' SIR2/SIRT2 'Small Domain'CATH (4.3.0)
B3.40.50.1220 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold TPP-binding domainCATH (4.3.0)
B3.30.1600.10 Alpha Beta 2-Layer Sandwich SIR2/SIRT2 'Small Domain' SIR2/SIRT2 'Small Domain'CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF02146Sir2 family (SIR2)Sir2 family- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
NAD-DEPENDENT PROTEIN DEACETYLASE -
C [auth E],
D [auth H]
CELLULAR TUMOR ANTIGEN P53

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
C [auth E],
D [auth H]
PharosP04637