Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
C [auth H]SCOP2B SuperfamilyTrypsin-like serine proteases 8042154 3000114 SCOP2B (2022-06-29)
D [auth G]SCOP2B SuperfamilyTrypsin-like serine proteases 8042154 3000114 SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
C [auth H]2.40.10.10 Mainly Beta Beta Barrel Thrombin, subunit H Trypsin-like serine proteasesCATH (4.3.0)
D [auth G]2.40.10.10 Mainly Beta Beta Barrel Thrombin, subunit H Trypsin-like serine proteasesCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
C [auth H],
D [auth G]
PF00089Trypsin (Trypsin)Trypsin- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth L],
B [auth M]
Thrombin light chain
C [auth H],
D [auth G]
Thrombin heavy chain
E [auth I],
F [auth J]
Hirudin variant-2 -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth L],
B [auth M]
IPR018992Thrombin light chainDomain
A [auth L],
B [auth M]
IPR037111Thrombin light chain domain superfamilyHomologous Superfamily
A [auth L],
B [auth M]
IPR003966Prothrombin/thrombinFamily
A [auth L],
B [auth M]
IPR018114Serine proteases, trypsin family, histidine active siteActive Site
A [auth L],
B [auth M]
IPR009003Peptidase S1, PA clanHomologous Superfamily
A [auth L],
B [auth M]
IPR033116Serine proteases, trypsin family, serine active siteActive Site
A [auth L],
B [auth M]
IPR001254Serine proteases, trypsin domainDomain
A [auth L],
B [auth M]
IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
A [auth L],
B [auth M]
IPR000001KringleDomain
A [auth L],
B [auth M]
IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
A [auth L],
B [auth M]
IPR051659Serine Protease S1 Domain-Containing ProteinFamily
A [auth L],
B [auth M]
IPR018056Kringle, conserved siteConserved Site
A [auth L],
B [auth M]
IPR013806Kringle-like foldHomologous Superfamily
A [auth L],
B [auth M]
IPR038178Kringle superfamilyHomologous Superfamily
A [auth L],
B [auth M]
IPR001314Peptidase S1A, chymotrypsin familyFamily
A [auth L],
B [auth M]
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
C [auth H],
D [auth G]
IPR018992Thrombin light chainDomain
C [auth H],
D [auth G]
IPR037111Thrombin light chain domain superfamilyHomologous Superfamily
C [auth H],
D [auth G]
IPR003966Prothrombin/thrombinFamily
C [auth H],
D [auth G]
IPR018114Serine proteases, trypsin family, histidine active siteActive Site
C [auth H],
D [auth G]
IPR009003Peptidase S1, PA clanHomologous Superfamily
C [auth H],
D [auth G]
IPR033116Serine proteases, trypsin family, serine active siteActive Site
C [auth H],
D [auth G]
IPR001254Serine proteases, trypsin domainDomain
C [auth H],
D [auth G]
IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
C [auth H],
D [auth G]
IPR000001KringleDomain
C [auth H],
D [auth G]
IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
C [auth H],
D [auth G]
IPR051659Serine Protease S1 Domain-Containing ProteinFamily
C [auth H],
D [auth G]
IPR018056Kringle, conserved siteConserved Site
C [auth H],
D [auth G]
IPR013806Kringle-like foldHomologous Superfamily
C [auth H],
D [auth G]
IPR038178Kringle superfamilyHomologous Superfamily
C [auth H],
D [auth G]
IPR001314Peptidase S1A, chymotrypsin familyFamily
C [auth H],
D [auth G]
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
E [auth I],
F [auth J]
IPR011061Hirudin/antistatinHomologous Superfamily
E [auth I],
F [auth J]
IPR000429Proteinase inhibitor I14, hirudinFamily
E [auth I],
F [auth J]
IPR024793Thrombin inhibitor hirudinHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A [auth L],
B [auth M]
PharosP00734
C [auth H],
D [auth G]
PharosP00734

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
E [auth I],
F [auth J]
TYS Parent Component: TYR

RESIDAA0172

PSI-MOD :  O4'-sulfo-L-tyrosine MOD:00181