Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BEUF08105e4ebkB3 A: alpha bundlesX: Four-helical up-and-down bundleH: HEPNT: Nucleotidyltransferase substrate binding subunit/domainF: EUF08105ECOD (1.6)
BNTP_transf_2e4ebkB2 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: NTP_transf_2ECOD (1.6)
AEUF08105e4ebkA1 A: alpha bundlesX: Four-helical up-and-down bundleH: HEPNT: Nucleotidyltransferase substrate binding subunit/domainF: EUF08105ECOD (1.6)
ANTP_transf_2e4ebkA2 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: NTP_transf_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
A, B
ARO:3002625ANT(4')-IIbANT(4')-IIb is a transposon-encoded aminoglycoside nucleotidyltransferase in P. aeruginosa.CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B
ARO:3000229ANT(4')aminoglycoside antibioticantibiotic inactivationCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF01909Nucleotidyltransferase domain (NTP_transf_2)Nucleotidyltransferase domainMembers of this family belong to a large family of nucleotidyltransferases [1]. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTa ...Members of this family belong to a large family of nucleotidyltransferases [1]. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug.
Domain
A, B
PF18280Nucleotidyltransferase, substrate binding domain (Ant-IIb_sub-bd)Nucleotidyltransferase, substrate binding domainThis domain is located on the central part of a nucleotidyltransferase from Pseudomonas aeruginosa (Ant(4')-IIb) and in other bacterial proteins. It shows a four-helical up-and-down bundle.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Aminoglycoside nucleotidyltransferase - -

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A, B
IYR Parent Component: TYR

RESIDAA0509

PSI-MOD :  3'-iodo-L-tyrosine MOD:01612
A, B
MSE Parent Component: MET

RESIDAA0509