4EZC

Crystal Structure of the UT-B Urea Transporter from Bos Taurus

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Urea transporter	8051264	4007272	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ammonium transporter	8055962	3001978	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Ammonium transporter	8055962	3001978	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ammonium transporter	8055962	3001978	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UT	e4ezcA1	A: alpha complex topology	X: Ammonium transporter-related (From Homology)	H: Ammonium transporter-related	T: Urea transporter	F: UT	ECOD (1.6)
B	UT	e4ezcB1	A: alpha complex topology	X: Ammonium transporter-related (From Homology)	H: Ammonium transporter-related	T: Urea transporter	F: UT	ECOD (1.6)
C	UT	e4ezcC1	A: alpha complex topology	X: Ammonium transporter-related (From Homology)	H: Ammonium transporter-related	T: Urea transporter	F: UT	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.3430.10	Mainly Alpha	Orthogonal Bundle	Ammonium transporter fold	Ammonium transporter AmtB like domains	CATH (4.3.0)
B	1.10.3430.10	Mainly Alpha	Orthogonal Bundle	Ammonium transporter fold	Ammonium transporter AmtB like domains	CATH (4.3.0)
C	1.10.3430.10	Mainly Alpha	Orthogonal Bundle	Ammonium transporter fold	Ammonium transporter AmtB like domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF03253	Urea transporter (UT)	Urea transporter	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Urea transporter 1	urea transmembrane transporter activity amide transmembrane transporter activity transporter activity transmembrane transporter activity urea channel activity passive transmembrane transporter activity channel activity identical protein binding protein binding binding	transmembrane transport one-carbon compound transport localization nitrogen compound transport transport amide transport urea transport cellular process establishment of localization urea transmembrane transport	cell periphery plasma membrane membrane cellular anatomical entity basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR004937	Urea transporter	Family
A, B, C	IPR029020	Ammonium/urea transporter	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C	OPM	Transmembrane	Alpha-helical polytopic	Ammonia/urea transporters/Na+ exporter	Urea transporter

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Urea Transporters	UT-B Urea Transporter

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.