4PE4

Crystal Structure of Calcium-loaded S100B bound to SC1475

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth A]	d4pe4a_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	Bovine (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
A [auth X]	d4pe4x_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	Bovine (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2B Superfamily	EF-hand	8040270	3001983	SCOP2B (2022-06-29)
A [auth X]	SCOP2B Superfamily	EF-hand	8040270	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	S_100	e4pe4A1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
A [auth X]	S_100	e4pe4X1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
A [auth X]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth X], B [auth A]	PF01023	S-100/ICaBP type calcium binding domain (S_100)	S-100/ICaBP type calcium binding domain	The S-100 domain is a subfamily of the EF-hand calcium binding proteins.	Domain
A [auth X], B [auth A]	PF00036	EF hand (EF-hand_1)	EF hand	The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typica ...	The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth X], B [auth A]	Protein S100-B	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity kinase inhibitor activity kinase regulator activity protein binding S100 protein binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity kinase inhibitor activity kinase regulator activity protein binding S100 protein binding identical protein binding protein homodimerization activity protein dimerization activity cytoskeletal protein binding tau protein binding RAGE receptor binding signaling receptor binding calcium-dependent protein binding transition metal ion binding zinc ion binding	metabolic process cellular process adaptive thermogenesis cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication metabolic process cellular process adaptive thermogenesis cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling multicellular organismal process regulation of monocyte chemotactic protein-1 production negative regulation of biological process negative regulation of chemokine production monocyte chemotactic protein-1 production regulation of cytokine production cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of monocyte chemotactic protein-1 production negative regulation of metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of chemokine production regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process chemokine production regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process regulation of protein metabolic process primary metabolic process translation regulation of primary metabolic process post-transcriptional regulation of gene expression regulation of translation protein metabolic process cellular developmental process developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell growth cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth sympathetic neuron projection extension nervous system development developmental growth involved in morphogenesis generation of neurons anatomical structure morphogenesis neuron development regulation of humoral immune response regulation of immune effector process humoral immune response immune response immune effector process complement activation positive regulation of humoral immune response positive regulation of immune response immune system process positive regulation of complement activation regulation of immune response regulation of immune system process positive regulation of immune effector process regulation of complement activation positive regulation of immune system process activation of immune response axonogenesis axon development cell morphogenesis involved in neuron differentiation cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation astrocyte differentiation astrocyte activation glial cell development astrocyte development gliogenesis response to stress defense response cell activation central nervous system development glial cell differentiation glial cell activation inflammatory response neuroinflammatory response cell adhesion behavior system process learning or memory nervous system process cognition phosphorylation phosphate-containing compound metabolic process phosphorus metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm extracellular region extracellular space membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth X], B [auth A]	IPR001751	S100/Calcium binding protein 7/8-like, conserved site	Conserved Site
A [auth X], B [auth A]	IPR002048	EF-hand domain	Domain
A [auth X], B [auth A]	IPR011992	EF-hand domain pair	Homologous Superfamily
A [auth X], B [auth A]	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A [auth X], B [auth A]	IPR028481	Protein S100-B	Family
A [auth X], B [auth A]	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.