5C6R

Crystal structure of PH domain of ASAP1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PH domain-like	8087021	3000134	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PH domain-like	8087021	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PH	e5c6rA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)
B	PH	e5c6rB1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
B	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Arf-GAP	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding phosphatidylinositol-3,4,5-trisphosphate binding cation binding metal ion binding modified amino acid binding phosphatidylserine binding	multicellular organismal process regulation of developmental process cellular developmental process cell projection organization negative regulation of biological process cell development negative regulation of dendritic spine development regulation of dendritic spine development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation multicellular organismal process regulation of developmental process cellular developmental process cell projection organization negative regulation of biological process cell development negative regulation of dendritic spine development regulation of dendritic spine development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process dendritic spine development regulation of biological process plasma membrane bounded cell projection organization negative regulation of developmental process biological regulation nervous system development generation of neurons neuron development cellular process protein localization localization cellular localization protein localization to cilium protein localization to organelle cellular macromolecule localization macromolecule localization plasma membrane tubulation membrane organization positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization positive regulation of biological process positive regulation of membrane tubulation regulation of plasma membrane organization plasma membrane organization endomembrane system organization positive regulation of cellular process regulation of membrane tubulation organelle assembly plasma membrane bounded cell projection assembly cellular component biogenesis organelle organization cellular component assembly cilium assembly cilium organization cell projection assembly postsynapse organization regulation of postsynapse organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization regulation of biological quality	intracellular organelle cellular anatomical structure intracellular anatomical structure podosome cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol synapse cell junction glutamatergic synapse intracellular organelle cellular anatomical structure intracellular anatomical structure podosome cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol synapse cell junction glutamatergic synapse membrane-bounded organelle Golgi membrane Golgi apparatus membrane intracellular membrane-bounded organelle endomembrane system bounding membrane of organelle organelle membrane neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree Golgi apparatus subcompartment organelle subcompartment trans-Golgi network membrane trans-Golgi network

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004148	BAR domain	Domain
A, B	IPR001849	Pleckstrin homology domain	Domain
A, B	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, B	IPR027267	AH/BAR domain superfamily	Homologous Superfamily
A, B	IPR038016	ASAP1, SH3 domain	Domain
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B	IPR043593	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein	Family
A, B	IPR038508	ArfGAP domain superfamily	Homologous Superfamily
A, B	IPR002110	Ankyrin repeat	Repeat
A, B	IPR037928	ASAP1, BAR domain	Domain
A, B	IPR001452	SH3 domain	Domain
A, B	IPR037844	ASAP, PH domain	Domain
A, B	IPR037278	ARFGAP/RecO-like zinc finger	Homologous Superfamily
A, B	IPR001164	Arf GTPase activating protein	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.