Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyDNA polymerase beta, N-terminal domain-like 8037849 3000524 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2B (2022-06-29)
B [auth C]SCOP2B SuperfamilyDNA polymerase beta, N-terminal domain-like 8037849 3000524 SCOP2B (2022-06-29)
B [auth C]SCOP2B SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2B (2022-06-29)
B [auth C]SCOP2B SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2B (2022-06-29)
C [auth E]SCOP2B SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2B (2022-06-29)
C [auth E]SCOP2B SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2B (2022-06-29)
D [auth G]SCOP2B SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2B (2022-06-29)
D [auth G]SCOP2B SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ADNA_pol_lambd_fe5ddyA3 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
AHHH_8e5ddyA1 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHH_8ECOD (1.6)
ADNA_pol_B_palme5ddyA2 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)
B [auth C]DNA_pol_lambd_fe5ddyC2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
B [auth C]HHH_8e5ddyC1 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHH_8ECOD (1.6)
B [auth C]DNA_pol_B_palme5ddyC3 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)
C [auth E]DNA_pol_lambd_fe5ddyE2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
C [auth E]DNA_pol_B_palme5ddyE1 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)
D [auth G]DNA_pol_lambd_fe5ddyG2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
D [auth G]DNA_pol_B_palme5ddyG1 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
B [auth C],
C [auth E],
D [auth G]
PF14716Helix-hairpin-helix domain (HHH_8)Helix-hairpin-helix domain- Domain
A,
B [auth C],
C [auth E],
D [auth G]
PF14791DNA polymerase beta thumb (DNA_pol_B_thumb)DNA polymerase beta thumb- Family
A,
B [auth C],
C [auth E],
D [auth G]
PF14792DNA polymerase beta palm (DNA_pol_B_palm)DNA polymerase beta palmThe catalytic region of DNA polymerase beta is split into three domains. An N-terminal fingers domain, a central palm domain and a C-terminal thumb domain. This entry represents the palm domain [1].Domain
A,
B [auth C],
C [auth E],
D [auth G]
PF10391Fingers domain of DNA polymerase lambda (DNA_pol_lambd_f)Fingers domain of DNA polymerase lambdaDNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the centr ...DNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
B [auth C],
C [auth E],
D [auth G]
DNA polymerase lambda

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A,
B [auth C],
C [auth E],
D [auth G]
PharosQ9UGP5