Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyCytochrome P450 8068633 3001061 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCytochrome P450 8068633 3001061 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyCytochrome P450 8068633 3001061 SCOP2B (2022-06-29)
DSCOP2 FamilyCytochrome P450 8068632 4001206 SCOP2 (2022-06-29)
DSCOP2 SuperfamilyCytochrome P450 8068633 3001061 SCOP2 (2022-06-29)
ESCOP2B SuperfamilyCytochrome P450 8068633 3001061 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyCytochrome P450 8068633 3001061 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
Ap450e5e58A1 A: alpha arraysX: Cytochrome P450 (From Topology)H: Cytochrome P450 (From Topology)T: Cytochrome P450F: p450ECOD (1.6)
Bp450e5e58B1 A: alpha arraysX: Cytochrome P450 (From Topology)H: Cytochrome P450 (From Topology)T: Cytochrome P450F: p450ECOD (1.6)
Cp450e5e58C1 A: alpha arraysX: Cytochrome P450 (From Topology)H: Cytochrome P450 (From Topology)T: Cytochrome P450F: p450ECOD (1.6)
Dp450e5e58D1 A: alpha arraysX: Cytochrome P450 (From Topology)H: Cytochrome P450 (From Topology)T: Cytochrome P450F: p450ECOD (1.6)
Ep450e5e58E1 A: alpha arraysX: Cytochrome P450 (From Topology)H: Cytochrome P450 (From Topology)T: Cytochrome P450F: p450ECOD (1.6)
Fp450e5e58F1 A: alpha arraysX: Cytochrome P450 (From Topology)H: Cytochrome P450 (From Topology)T: Cytochrome P450F: p450ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.10.630.10 Mainly Alpha Orthogonal Bundle Cytochrome p450 Cytochrome P450CATH (4.3.0)
B1.10.630.10 Mainly Alpha Orthogonal Bundle Cytochrome p450 Cytochrome P450CATH (4.3.0)
C1.10.630.10 Mainly Alpha Orthogonal Bundle Cytochrome p450 Cytochrome P450CATH (4.3.0)
D1.10.630.10 Mainly Alpha Orthogonal Bundle Cytochrome p450 Cytochrome P450CATH (4.3.0)
E1.10.630.10 Mainly Alpha Orthogonal Bundle Cytochrome p450 Cytochrome P450CATH (4.3.0)
F1.10.630.10 Mainly Alpha Orthogonal Bundle Cytochrome p450 Cytochrome P450CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00067Cytochrome P450 (p450)Cytochrome P450Cytochrome P450s are haem-thiolate proteins [6] involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, a ...Cytochrome P450s are haem-thiolate proteins [6] involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures [6].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Cytochrome P450 family 2 subfamily B

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR002401Cytochrome P450, E-class, group IFamily
A, B, C, D, E
IPR017972Cytochrome P450, conserved siteConserved Site
A, B, C, D, E
IPR050182Cytochrome P450 family 2Family
A, B, C, D, E
IPR001128Cytochrome P450Family
A, B, C, D, E
IPR008068Cytochrome P450, E-class, group I, CYP2B-likeFamily
A, B, C, D, E
IPR036396Cytochrome P450 superfamilyHomologous Superfamily