Annotations: 5GXI

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ANAPC4_WD40_17	e5gxiA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_17	ECOD (1.6)
A	ANAPC4_WD40_13	e5gxiA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_13	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF12894	Anaphase-promoting complex subunit 4 WD40 domain (ANAPC4_WD40)	Anaphase-promoting complex subunit 4 WD40 domain	-	Repeat
A	PF21720	MIOS, WD40 repeat (MIOS_WD40)	MIOS, WD40 repeat	-	Repeat
A	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Gem-associated protein 5	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding U4atac snRNA binding U4 snRNA binding mRNA 3'-UTR binding mRNA binding RNA 7-methylguanosine cap binding RNA cap binding ribonucleoprotein complex binding protein-containing complex binding RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding U4atac snRNA binding U4 snRNA binding mRNA 3'-UTR binding mRNA binding RNA 7-methylguanosine cap binding RNA cap binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of cellular process cellular biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression protein metabolic process regulation of biosynthetic process regulation of biological process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of cellular process cellular biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression protein metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of translation regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process ribonucleoprotein complex biogenesis RNA metabolic process mRNA processing protein-RNA complex assembly nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process protein-RNA complex organization RNA processing RNA splicing spliceosomal snRNP assembly nucleobase-containing compound biosynthetic process mRNA metabolic process nucleic acid metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen Gemini of coiled bodies membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen Gemini of coiled bodies membrane cytoplasm cytosol SMN-Sm protein complex protein-containing complex Sm-like protein family complex SMN complex RNA polymerase II transcription regulator complex nuclear protein-containing complex transcription regulator complex SMN-Gemin2 complex
B	RNA (5'-R(AAPUPUPUPUPUPGPAPG)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019775	WD40 repeat, conserved site	Conserved Site
A	IPR052640	Gem-associated protein 5	Family
A	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily	Homologous Superfamily
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A	IPR024977	Anaphase-promoting complex subunit 4-like, WD40 domain	Domain
A	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A	IPR001680	WD40 repeat	Repeat
A	IPR020472	G-protein beta WD-40 repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8TEQ6	medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.