Annotations: 5I0A

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Intein_splicing	e5i0aA1	A: beta complex topology	X: Hedgehog/intein (From Homology)	H: Hedgehog/intein	T: Hint	F: Intein_splicing	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.170.16.10	Mainly Beta	Beta Complex	Endonuclease - Pi-scei	Chain A, domain 1	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Intein	DNA endonuclease activity endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on a nucleic acid hydrolase activity catalytic activity DNA nuclease activity cation binding manganese ion binding transition metal ion binding ion binding binding DNA endonuclease activity endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on a nucleic acid hydrolase activity catalytic activity DNA nuclease activity cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding ATP-dependent activity, acting on DNA ATP-dependent activity DNA binding organic cyclic compound binding damaged DNA binding nucleic acid binding DNA strand exchange activity DNA damage sensor activity molecular sensor activity ATP-dependent DNA damage sensor activity molecular function regulator activity magnesium ion binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides single-stranded DNA binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process DNA recombination metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process intron homing cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process DNA recombination metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process intron homing response to chemical response to antibiotic SOS response response to light stimulus response to radiation response to abiotic stimulus response to UV UV protection DNA strand invasion intein-mediated protein splicing gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing protein metabolic process protein splicing recombinational repair DNA repair	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR049261	RecA-like, C-terminal	Domain
A	IPR036844	Hint domain superfamily	Homologous Superfamily
A	IPR006142	Intein	Domain
A	IPR004042	Intein DOD homing endonuclease, central region	Domain
A	IPR020587	DNA recombination and repair protein RecA, monomer-monomer interface	Domain
A	IPR006141	Intein N-terminal splicing region	PTM
A	IPR003593	AAA+ ATPase domain	Domain
A	IPR020584	DNA recombination/repair protein RecA, conserved site	Conserved Site
A	IPR023400	DNA recombination and repair protein RecA, C-terminal, superfamily	Homologous Superfamily
A	IPR003586	Hint domain C-terminal	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR030934	Intein C-terminal splicing region	Conserved Site
A	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain	Domain
A	IPR027434	Homing endonuclease	Homologous Superfamily
A	IPR004860	Homing endonuclease, LAGLIDADG domain	Domain
A	IPR003587	Hint domain N-terminal	Domain
A	IPR049428	RecA-like, N-terminal	Domain
A	IPR013765	DNA recombination and repair protein RecA	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.