5JJM

Crystal Structure of Homodimeric Androgen Receptor Ligand-Binding Domain bound to DHT and LxxLL peptide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5jjma_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Androgen receptor	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth D]	d5jjmd_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Androgen receptor	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth C]	d5jjmc_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Androgen receptor	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth B]	d5jjmb_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Androgen receptor	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8037208	3001442	SCOP2B (2022-06-29)
G [auth D]	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8037208	3001442	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8037208	3001442	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8037208	3001442	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hormone_recep_1	e5jjmA1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep_1	ECOD (1.6)
G [auth D]	Hormone_recep_1	e5jjmD1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep_1	ECOD (1.6)
E [auth C]	Hormone_recep_1	e5jjmC1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep_1	ECOD (1.6)
C [auth B]	Hormone_recep_1	e5jjmB1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)
G [auth D]	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)
E [auth C]	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)
C [auth B]	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E [auth C], G [auth D]	PF00104	Ligand-binding domain of nuclear hormone receptor (Hormone_recep)	Ligand-binding domain of nuclear hormone receptor	This all helical domain is involved in binding the hormone in these receptors.	Domain
C [auth B]	PF00104	Ligand-binding domain of nuclear hormone receptor (Hormone_recep)	Ligand-binding domain of nuclear hormone receptor	This all helical domain is involved in binding the hormone in these receptors.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E [auth C], G [auth D]	Androgen receptor	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding hormone binding androgen binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding hormone binding androgen binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding estrogen response element binding RNA polymerase II cis-regulatory region sequence-specific DNA binding nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity molecular adaptor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity ATPase binding protein binding enzyme binding signaling receptor binding POU domain binding protein domain specific binding G protein-coupled receptor activity transmembrane signaling receptor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding protein-containing complex binding chromatin binding molecular condensate scaffold activity protein-macromolecule adaptor activity basal transcription machinery binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding transcription coregulator binding transcription coactivator binding steroid binding lipid binding beta-catenin binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development spermatogenesis sexual reproduction multicellular organismal reproductive process male gamete generation gamete generation epithelial cell differentiation involved in prostate gland development epithelium development cellular developmental process prostate gland development gland development urogenital system development tissue development epithelial cell differentiation cell differentiation cellular process branching involved in mammary gland duct morphogenesis multi-multicellular organism process mammary gland morphogenesis maternal process involved in female pregnancy mammary gland development branching morphogenesis of an epithelial tube tertiary branching involved in mammary gland duct morphogenesis tube morphogenesis gland morphogenesis mammary gland branching involved in pregnancy animal organ morphogenesis epithelial tube morphogenesis female pregnancy tube development morphogenesis of an epithelium mammary gland duct morphogenesis tissue morphogenesis anatomical structure morphogenesis mammary gland epithelium development morphogenesis of a branching structure multi-organism reproductive process morphogenesis of a branching epithelium cellular response to stimulus regulation of cellular process intracellular receptor signaling pathway response to stimulus response to lipid signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone androgen receptor signaling pathway signal transduction nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus response to organic cyclic compound steroid hormone receptor signaling pathway cellular response to hormone stimulus regulation of biological process response to endogenous stimulus biological regulation cellular response to organic cyclic compound cellular response to chemical stimulus response to chemical cellular response to lipid nuclear receptor-mediated signaling pathway cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process lateral sprouting from an epithelium lateral sprouting involved in mammary gland duct morphogenesis cell-cell signaling fertilization single fertilization positive regulation of cellular component organization regulation of cellular component organization cellular component organization plasma membrane organization cellular component organization or biogenesis integrin biosynthetic process endomembrane system organization membrane organization positive regulation of integrin biosynthetic process regulation of integrin biosynthetic process cell surface receptor signaling pathway insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway regulation of developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation estrogen receptor signaling pathway regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process regulation of miRNA metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of RNA metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process regulation of miRNA transcription embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development intracellular signaling cassette MAPK cascade positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus positive regulation of insulin-like growth factor receptor signaling pathway regulation of insulin-like growth factor receptor signaling pathway regulation of signaling regulation of response to stimulus regulation of cell communication positive regulation of signaling positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of molecular function regulation of molecular function regulation of DNA-binding transcription factor activity system process regulation of systemic arterial blood pressure circulatory system process regulation of blood pressure regulation of biological quality blood circulation response to estrogen cellular response to estrogen stimulus negative regulation of signaling negative regulation of biological process regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process apoptotic process programmed cell death regulation of apoptotic signaling pathway protein localization regulation of localization cellular localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane localization regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane prostate gland epithelium morphogenesis prostate gland morphogenesis negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process regulation of reproductive process animal organ formation activation of prostate induction by androgen receptor signaling pathway regulation of animal organ morphogenesis cell fate commitment pattern specification process positive regulation of morphogenesis of an epithelium morphogenesis of an epithelial bud regulation of anatomical structure morphogenesis positive regulation of reproductive process morphogenesis of an epithelial fold regionalization regulation of cell fate specification positive regulation of animal organ morphogenesis regulation of animal organ formation developmental induction regulation of morphogenesis of a branching structure embryonic morphogenesis prostatic bud formation cell fate specification positive regulation of multicellular organismal process prostate induction specification of animal organ identity regulation of morphogenesis of an epithelium regulation of multicellular organismal process morphogenesis of embryonic epithelium regulation of cell fate commitment regulation of prostatic bud formation anatomical structure formation involved in morphogenesis prostate field specification organ induction multicellular organism growth developmental growth growth negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of transcription by RNA polymerase II seminiferous tubule development male somatic sex determination sex determination male sex determination somatic sex determination Leydig cell differentiation cellular component biogenesis organelle organization cellular component assembly organelle assembly non-membrane-bounded organelle assembly cell development cell morphogenesis epithelial cell development epithelial cell morphogenesis positive regulation of cell population proliferation regulation of epithelial cell proliferation involved in prostate gland development positive regulation of epithelial cell proliferation epithelial cell proliferation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development regulation of intracellular signal transduction positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of growth regulation of developmental growth cellular response to testosterone stimulus response to ketone response to oxygen-containing compound cellular response to oxygen-containing compound response to testosterone cellular response to ketone negative regulation of integrin biosynthetic process negative regulation of cellular component organization positive regulation of phosphorylation positive regulation of phosphorus metabolic process phosphorylation positive regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process regulation of phosphorus metabolic process regulation of phosphorylation phosphorus metabolic process positive regulation of transcription by RNA polymerase III transcription by RNA polymerase III regulation of transcription by RNA polymerase III organ growth prostate gland growth positive regulation of intracellular estrogen receptor signaling pathway regulation of intracellular estrogen receptor signaling pathway regulation of intracellular steroid hormone receptor signaling pathway positive regulation of intracellular steroid hormone receptor signaling pathway male genitalia morphogenesis genitalia development male anatomical structure morphogenesis male genitalia development genitalia morphogenesis mammary gland lobule development mammary gland alveolus development	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol protein-containing complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle cell periphery plasma membrane membrane
B [auth M], D [auth F], F [auth K], H [auth L]	Unknown peptide	-	-	-
C [auth B]	Androgen receptor	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding hormone binding androgen binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding hormone binding androgen binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding estrogen response element binding RNA polymerase II cis-regulatory region sequence-specific DNA binding nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity molecular adaptor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity ATPase binding protein binding enzyme binding signaling receptor binding POU domain binding protein domain specific binding G protein-coupled receptor activity transmembrane signaling receptor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding protein-containing complex binding chromatin binding molecular condensate scaffold activity protein-macromolecule adaptor activity basal transcription machinery binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding transcription coregulator binding transcription coactivator binding steroid binding lipid binding beta-catenin binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development spermatogenesis sexual reproduction multicellular organismal reproductive process male gamete generation gamete generation epithelial cell differentiation involved in prostate gland development epithelium development cellular developmental process prostate gland development gland development urogenital system development tissue development epithelial cell differentiation cell differentiation cellular process branching involved in mammary gland duct morphogenesis multi-multicellular organism process mammary gland morphogenesis maternal process involved in female pregnancy mammary gland development branching morphogenesis of an epithelial tube tertiary branching involved in mammary gland duct morphogenesis tube morphogenesis gland morphogenesis mammary gland branching involved in pregnancy animal organ morphogenesis epithelial tube morphogenesis female pregnancy tube development morphogenesis of an epithelium mammary gland duct morphogenesis tissue morphogenesis anatomical structure morphogenesis mammary gland epithelium development morphogenesis of a branching structure multi-organism reproductive process morphogenesis of a branching epithelium cellular response to stimulus regulation of cellular process intracellular receptor signaling pathway response to stimulus response to lipid signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone androgen receptor signaling pathway signal transduction nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus response to organic cyclic compound steroid hormone receptor signaling pathway cellular response to hormone stimulus regulation of biological process response to endogenous stimulus biological regulation cellular response to organic cyclic compound cellular response to chemical stimulus response to chemical cellular response to lipid nuclear receptor-mediated signaling pathway cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process lateral sprouting from an epithelium lateral sprouting involved in mammary gland duct morphogenesis cell-cell signaling fertilization single fertilization positive regulation of cellular component organization regulation of cellular component organization cellular component organization plasma membrane organization cellular component organization or biogenesis integrin biosynthetic process endomembrane system organization membrane organization positive regulation of integrin biosynthetic process regulation of integrin biosynthetic process cell surface receptor signaling pathway insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway regulation of developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation estrogen receptor signaling pathway regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process regulation of miRNA metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of RNA metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process regulation of miRNA transcription embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development intracellular signaling cassette MAPK cascade positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus positive regulation of insulin-like growth factor receptor signaling pathway regulation of insulin-like growth factor receptor signaling pathway regulation of signaling regulation of response to stimulus regulation of cell communication positive regulation of signaling positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of molecular function regulation of molecular function regulation of DNA-binding transcription factor activity system process regulation of systemic arterial blood pressure circulatory system process regulation of blood pressure regulation of biological quality blood circulation response to estrogen cellular response to estrogen stimulus negative regulation of signaling negative regulation of biological process regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process apoptotic process programmed cell death regulation of apoptotic signaling pathway protein localization regulation of localization cellular localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane localization regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane prostate gland epithelium morphogenesis prostate gland morphogenesis negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process regulation of reproductive process animal organ formation activation of prostate induction by androgen receptor signaling pathway regulation of animal organ morphogenesis cell fate commitment pattern specification process positive regulation of morphogenesis of an epithelium morphogenesis of an epithelial bud regulation of anatomical structure morphogenesis positive regulation of reproductive process morphogenesis of an epithelial fold regionalization regulation of cell fate specification positive regulation of animal organ morphogenesis regulation of animal organ formation developmental induction regulation of morphogenesis of a branching structure embryonic morphogenesis prostatic bud formation cell fate specification positive regulation of multicellular organismal process prostate induction specification of animal organ identity regulation of morphogenesis of an epithelium regulation of multicellular organismal process morphogenesis of embryonic epithelium regulation of cell fate commitment regulation of prostatic bud formation anatomical structure formation involved in morphogenesis prostate field specification organ induction multicellular organism growth developmental growth growth negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of transcription by RNA polymerase II seminiferous tubule development male somatic sex determination sex determination male sex determination somatic sex determination Leydig cell differentiation cellular component biogenesis organelle organization cellular component assembly organelle assembly non-membrane-bounded organelle assembly cell development cell morphogenesis epithelial cell development epithelial cell morphogenesis positive regulation of cell population proliferation regulation of epithelial cell proliferation involved in prostate gland development positive regulation of epithelial cell proliferation epithelial cell proliferation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development regulation of intracellular signal transduction positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of growth regulation of developmental growth cellular response to testosterone stimulus response to ketone response to oxygen-containing compound cellular response to oxygen-containing compound response to testosterone cellular response to ketone negative regulation of integrin biosynthetic process negative regulation of cellular component organization positive regulation of phosphorylation positive regulation of phosphorus metabolic process phosphorylation positive regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process regulation of phosphorus metabolic process regulation of phosphorylation phosphorus metabolic process positive regulation of transcription by RNA polymerase III transcription by RNA polymerase III regulation of transcription by RNA polymerase III organ growth prostate gland growth positive regulation of intracellular estrogen receptor signaling pathway regulation of intracellular estrogen receptor signaling pathway regulation of intracellular steroid hormone receptor signaling pathway positive regulation of intracellular steroid hormone receptor signaling pathway male genitalia morphogenesis genitalia development male anatomical structure morphogenesis male genitalia development genitalia morphogenesis mammary gland lobule development mammary gland alveolus development	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol protein-containing complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle cell periphery plasma membrane membrane
I [auth G], J [auth H], K [auth I], L [auth J]	uba3-derived peptide	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein heterodimerization activity protein binding protein dimerization activity aminoacyltransferase activity ubiquitin-like protein transferase activity NEDD8 transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity NEDD8 activating enzyme activity ubiquitin-like modifier activating enzyme activity ligase activity, forming carbon-sulfur bonds ligase activity ATP-dependent activity identical protein binding	organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein neddylation protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of biological process regulation of cellular process biological regulation organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein neddylation protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of biological process regulation of cellular process biological regulation cellular process cell cycle regulation of cell cycle endomitotic cell cycle mitotic cell cycle proteolysis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E [auth C], G [auth D]	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
A, E [auth C], G [auth D]	IPR001103	Androgen receptor	Family
A, E [auth C], G [auth D]	IPR050200	Nuclear hormone receptor family NR3 subfamily	Family
A, E [auth C], G [auth D]	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A, E [auth C], G [auth D]	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
A, E [auth C], G [auth D]	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily
C [auth B]	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
C [auth B]	IPR001103	Androgen receptor	Family
C [auth B]	IPR050200	Nuclear hormone receptor family NR3 subfamily	Family
C [auth B]	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
C [auth B]	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
C [auth B]	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily
I [auth G], J [auth H], K [auth I], L [auth J]	IPR030468	NEDD8-activating enzyme E1 catalytic subunit, N-terminal domain	Domain
I [auth G], J [auth H], K [auth I], L [auth J]	IPR014929	E2 binding	Domain
I [auth G], J [auth H], K [auth I], L [auth J]	IPR045886	ThiF/MoeB/HesA family	Family
I [auth G], J [auth H], K [auth I], L [auth J]	IPR000594	THIF-type NAD/FAD binding fold	Domain
I [auth G], J [auth H], K [auth I], L [auth J]	IPR035985	Ubiquitin-activating enzyme	Homologous Superfamily
I [auth G], J [auth H], K [auth I], L [auth J]	IPR033127	Ubiquitin-activating enzyme E1, Cys active site	Active Site
I [auth G], J [auth H], K [auth I], L [auth J]	IPR023318	Ubiquitin activating enzyme, alpha domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, E [auth C], G [auth D]	Pharos: P10275	androgen insensitivity syndrome Kennedy disease prostate cancer breast cancer hypospadias 1, X-linked astrocytic tumor protoplasmic astrocytoma pilocytic astrocytoma breast carcinoma Bulbospinal neuronopathy, X-linked recessive hypertensive disorder childhood cerebral astrocytoma anaplastic astrocytoma partial androgen insensitivity syndrome juvenile pilocytic astrocytoma androgen insensitivity syndrome Kennedy disease prostate cancer breast cancer hypospadias 1, X-linked astrocytic tumor protoplasmic astrocytoma pilocytic astrocytoma breast carcinoma Bulbospinal neuronopathy, X-linked recessive hypertensive disorder childhood cerebral astrocytoma anaplastic astrocytoma partial androgen insensitivity syndrome juvenile pilocytic astrocytoma androgenetic alopecia female infertility fibrillary astrocytoma male infertility prostate intraepithelial neoplasia gestational diabetes subependymal giant cell astrocytoma alopecia leukemia male breast carcinoma gemistocytic astrocytoma glioblastoma malignant mesothelioma hereditary angioedema psoriasis spinal muscular atrophy hypopituitarism inherited aplastic anemia alcohol withdrawal neurodegenerative disease cutaneous lupus erythematosus pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia depressive disorder Klinefelter syndrome familial prostate carcinoma astrocytoma (excluding glioblastoma) primitive neuroectodermal tumor atypical teratoid rhabdoid tumor prostate carcinoma pseudohermaphroditism medulloblastoma Noonan syndrome intellectual disability pancreatic intraductal papillary-mucinous carcinoma Diamond-Blackfan anemia pituitary cancer endometriosis large cell medulloblastoma aplastic anemia atopic eczema prostate adenocarcinoma autism malignant ependymoma hepatocellular carcinoma breast fibrocystic disease carcinoma cerebral astrocytoma schizophrenia hypogonadotropic hypogonadism complete androgen insensitivity syndrome cryptorchidism osteosarcoma pancreatic intraductal papillary-mucinous neoplasm interstitial cystitis diffuse astrocytoma polycystic ovary syndrome male reproductive system disease
C [auth B]	Pharos: P10275	androgen insensitivity syndrome Kennedy disease prostate cancer breast cancer hypospadias 1, X-linked astrocytic tumor protoplasmic astrocytoma pilocytic astrocytoma breast carcinoma Bulbospinal neuronopathy, X-linked recessive hypertensive disorder childhood cerebral astrocytoma anaplastic astrocytoma partial androgen insensitivity syndrome juvenile pilocytic astrocytoma androgen insensitivity syndrome Kennedy disease prostate cancer breast cancer hypospadias 1, X-linked astrocytic tumor protoplasmic astrocytoma pilocytic astrocytoma breast carcinoma Bulbospinal neuronopathy, X-linked recessive hypertensive disorder childhood cerebral astrocytoma anaplastic astrocytoma partial androgen insensitivity syndrome juvenile pilocytic astrocytoma androgenetic alopecia female infertility fibrillary astrocytoma male infertility prostate intraepithelial neoplasia gestational diabetes subependymal giant cell astrocytoma alopecia leukemia male breast carcinoma gemistocytic astrocytoma glioblastoma malignant mesothelioma hereditary angioedema psoriasis spinal muscular atrophy hypopituitarism inherited aplastic anemia alcohol withdrawal neurodegenerative disease cutaneous lupus erythematosus pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia depressive disorder Klinefelter syndrome familial prostate carcinoma astrocytoma (excluding glioblastoma) primitive neuroectodermal tumor atypical teratoid rhabdoid tumor prostate carcinoma pseudohermaphroditism medulloblastoma Noonan syndrome intellectual disability pancreatic intraductal papillary-mucinous carcinoma Diamond-Blackfan anemia pituitary cancer endometriosis large cell medulloblastoma aplastic anemia atopic eczema prostate adenocarcinoma autism malignant ependymoma hepatocellular carcinoma breast fibrocystic disease carcinoma cerebral astrocytoma schizophrenia hypogonadotropic hypogonadism complete androgen insensitivity syndrome cryptorchidism osteosarcoma pancreatic intraductal papillary-mucinous neoplasm interstitial cystitis diffuse astrocytoma polycystic ovary syndrome male reproductive system disease
I [auth G], J [auth H], K [auth I], L [auth J]	Pharos: Q8TBC4	amyotrophic lateral sclerosis lymphoplasmacytic lymphoma dermatomyositis myopathy juvenile dermatomyositis plasma cell myeloma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B [auth M], D [auth F], F [auth K], H [auth L]	FME	Parent Component: MET RESID: AA0021 , AA0566 PSI-MOD : N-formyl-L-methionine residue MOD:00030 , N-formyl-L-methionine (Met) MOD:00482 , N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet) MOD:01890 , N-[(L-histidin-1'-yl)methyl]-L-methionine (Met) MOD:01891
C [auth B]	SNC	Parent Component: CYS RESID: AA0021 , AA0566

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.