Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad5khia_ All beta proteins Double-stranded beta-helix cAMP-binding domain-like cAMP-binding domain HCN pacemaker channel Mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilycAMP-binding domain-like 8039776 3000084 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AcNMP_binding_1e5khiA1 A: beta sandwichesX: jelly-rollH: Double-stranded beta-helix (From Topology)T: Double-stranded beta-helixF: cNMP_binding_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.10.287.630 Mainly Alpha Orthogonal Bundle Helix Hairpins Helix hairpin binCATH (4.3.0)
A2.60.120.10 Mainly Beta Sandwich Jelly Rolls Jelly RollsCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00027Cyclic nucleotide-binding domain (cNMP_binding)Cyclic nucleotide-binding domainThis domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
CSX Parent Component: CYS

RESIDAA0451

PSI-MOD :  2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide MOD:01380