5QHG

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NU000442a

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	NUDIX_1	e5qhgA1	A: a+b two layers	X: beta-Grasp	H: Nudix (From Topology)	T: Nudix	F: NUDIX_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00293	NUDIX domain (NUDIX)	NUDIX domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Peroxisomal coenzyme A diphosphatase NUDT7	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding snoRNA binding nucleic acid binding pyrophosphatase activity coenzyme A diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding snoRNA binding nucleic acid binding pyrophosphatase activity coenzyme A diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity manganese ion binding transition metal ion binding	nucleoside phosphate metabolic process catabolic process organophosphate catabolic process primary metabolic process purine-containing compound catabolic process coenzyme A catabolic process nucleoside phosphate catabolic process nucleobase-containing compound catabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process cellular catabolic process sulfur compound catabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process nucleoside phosphate metabolic process catabolic process organophosphate catabolic process primary metabolic process purine-containing compound catabolic process coenzyme A catabolic process nucleoside phosphate catabolic process nucleobase-containing compound catabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process cellular catabolic process sulfur compound catabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process sulfur compound metabolic process amide metabolic process phosphorus metabolic process coenzyme A metabolic process oxoacid metabolic process fatty-acyl-CoA catabolic process organic acid catabolic process organic acid metabolic process fatty acid derivative catabolic process butyryl-CoA catabolic process monocarboxylic acid catabolic process acyl-CoA metabolic process carboxylic acid catabolic process fatty-acyl-CoA metabolic process thioester metabolic process fatty acid metabolic process lipid catabolic process carboxylic acid metabolic process fatty acid catabolic process fatty acid derivative metabolic process monocarboxylic acid metabolic process small molecule catabolic process lipid metabolic process propionyl-CoA catabolic process propionyl-CoA metabolic process developmental process fat cell differentiation cellular developmental process brown fat cell differentiation cell differentiation malonyl-CoA metabolic process malonyl-CoA catabolic process medium-chain fatty-acyl-CoA catabolic process medium-chain fatty-acyl-CoA metabolic process acetyl-CoA metabolic process acetyl-CoA catabolic process nucleoside diphosphate metabolic process succinyl-CoA catabolic process succinyl-CoA metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle peroxisome microbody cytoplasm intracellular membrane-bounded organelle cytosol peroxisomal matrix membrane-enclosed lumen intracellular organelle lumen organelle lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle peroxisome microbody cytoplasm intracellular membrane-bounded organelle cytosol peroxisomal matrix membrane-enclosed lumen intracellular organelle lumen organelle lumen microbody lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000086	NUDIX hydrolase domain	Domain
A	IPR045121	Coenzyme A pyrophosphatase	Family
A	IPR015797	NUDIX hydrolase-like domain superfamily	Homologous Superfamily
A	IPR000059	NUDIX hydrolase, NudL, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P0C024	liver cancer breast cancer glioblastoma ovarian cancer congestive heart failure invasive ductal breast carcinoma liver neoplasm pancreatic ductal adenocarcinoma ductal breast carcinoma in situ large cell medulloblastoma osteosarcoma ulcerative colitis

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	CSO	Parent Component: CYS RESID: AA0205 PSI-MOD : L-cysteine sulfenic acid MOD:00210
A	HYP	Parent Component: PRO RESID: AA0205 , AA0030 PSI-MOD : L-cysteine sulfenic acid MOD:00210 , 4-hydroxy-L-proline MOD:00039

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.