Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyPI3K inter-SH2 coiled-coil domain 8061497 3002111 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
API3K_C2e5swtA3 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: C2 domain (From Topology)T: C2 domainF: PI3K_C2ECOD (1.6)
API3Kae5swtA4 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: PI3KaECOD (1.6)
API3K_rbde5swtA1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: PI3K_rbdECOD (1.6)
API3K_p85Be5swtA2 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: PI3K_p85BECOD (1.6)
API3_PI4_kinasee5swtA5 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: PI3_PI4_kinaseECOD (1.6)
BPI3K_P85_iSH2e5swtB2 A: alpha bundlesX: YscO-likeH: Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain (From Topology)T: Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainF: PI3K_P85_iSH2ECOD (1.6)
BSH2e5swtB1 A: a+b two layersX: SH2 (From Topology)H: SH2 (From Topology)T: SH2F: SH2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
B1.10.287.1490 Mainly Alpha Orthogonal Bundle Helix Hairpins CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00613Phosphoinositide 3-kinase family, accessory domain (PIK domain) (PI3Ka)Phosphoinositide 3-kinase family, accessory domain (PIK domain)- Repeat
PF02192PI3-kinase family, p85-binding domain (PI3K_p85B)PI3-kinase family, p85-binding domain- Family
PF00792Phosphoinositide 3-kinase C2 (PI3K_C2)Phosphoinositide 3-kinase C2Phosphoinositide 3-kinase region postulated to contain a C2 domain. Outlier of Pfam:PF00168 family.Domain
PF00794PI3-kinase family, ras-binding domain (PI3K_rbd)PI3-kinase family, ras-binding domainCertain members of the PI3K family possess Ras-binding domains in their N-termini. These regions show some similarity (although not highly significant similarity) to Ras-binding Pfam:PF00788 domains (unpublished observation).Domain
PF00454Phosphatidylinositol 3- and 4-kinase (PI3_PI4_kinase)Phosphatidylinositol 3- and 4-kinase- Family
PF00017SH2 domain (SH2)SH2 domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Phosphatidylinositol 3-kinase regulatory subunit alpha

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR015433Phosphatidylinositol kinaseFamily
IPR016024Armadillo-type foldHomologous Superfamily
IPR037704PI3Kalpha, catalytic domainDomain
IPR002420C2 phosphatidylinositol 3-kinase-type domainDomain
IPR018936Phosphatidylinositol 3/4-kinase, conserved siteConserved Site
IPR000403Phosphatidylinositol 3-/4-kinase, catalytic domainDomain
IPR001263Phosphoinositide 3-kinase, accessory (PIK) domainDomain
IPR042236Phosphoinositide 3-kinase, accessory (PIK) domain superfamilyHomologous Superfamily
IPR036940Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyHomologous Superfamily
IPR003113Phosphatidylinositol 3-kinase, adaptor-binding domainDomain
IPR011009Protein kinase-like domain superfamilyHomologous Superfamily
IPR000341Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domainDomain
IPR035892C2 domain superfamilyHomologous Superfamily
IPR029071Ubiquitin-like domain superfamilyHomologous Superfamily
IPR036028SH3-like domain superfamilyHomologous Superfamily
IPR008936Rho GTPase activation proteinHomologous Superfamily
IPR035020PI3K p85 subunit, C-terminal SH2 domainDomain
IPR035591Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domainDomain
IPR032498PI3K regulatory subunit p85-related , inter-SH2 domainDomain
IPR001452SH3 domainDomain
IPR035022PI3K p85 subunit, N-terminal SH2 domainDomain
IPR036860SH2 domain superfamilyHomologous Superfamily
IPR000980SH2 domainDomain
IPR000198Rho GTPase-activating protein domainDomain
IPR044124PIK3R1, inter-SH2 domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP42336
PharosP27986

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
SEP Parent Component: SER

RESIDAA0037

PSI-MOD :  O-phospho-L-serine MOD:00046