Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRegulator of G-protein signaling, RGS 8034089 3000835 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyProtein kinase-like (PK-like) 8034093 3000066 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPH domain-like 8034091 3000134 SCOP2B (2022-06-29)
C [auth G]SCOP2B SuperfamilyTransducin (heterotrimeric G protein), gamma chain 8070798 3001771 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APHe5ukmA2 A: beta barrelsX: PH domain-likeH: PH domain-like (From Topology)T: PH domain-likeF: PHECOD (1.6)
ARGSe5ukmA3 A: alpha bundlesX: Regulator of G-protein signaling, RGS (From Topology)H: Regulator of G-protein signaling, RGS (From Topology)T: Regulator of G-protein signaling, RGSF: RGSECOD (1.6)
APkinase_Tyre5ukmA1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
BANAPC4_WD40_3e5ukmB1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_3ECOD (1.6)
C [auth G]G-gammae5ukmG1 A: extended segmentsX: Transducin (heterotrimeric G protein), gamma chain (From Topology)H: Transducin (heterotrimeric G protein), gamma chain (From Topology)T: Transducin (heterotrimeric G protein), gamma chainF: G-gammaECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00615Regulator of G protein signaling domain (RGS)Regulator of G protein signaling domainRGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.Domain
PF00069Protein kinase domain (Pkinase)Protein kinase domain- Domain
PF00169PH domain (PH)PH domainPH stands for pleckstrin homology.Domain
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Beta-adrenergic receptor kinase 1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
C [auth G]Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP62873
C [auth G]PharosP59768