6A3V

Complex structure of human 4-1BB and 4-1BBL

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	TNFR_c6	e6a3vB1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
B	TNFRSF5	e6a3vB3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF5	ECOD (1.6)
B	TNFRSF14	e6a3vB2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
D	TNFR_c6	e6a3vD2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
D	TNFRSF5	e6a3vD3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF5	ECOD (1.6)
D	TNFRSF14	e6a3vD1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
F	TNFR_c6	e6a3vF2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
F	TNFRSF5	e6a3vF1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF5	ECOD (1.6)
F	TNFRSF14	e6a3vF3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
H	TNFR_c6	e6a3vH3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
H	TNFRSF14	e6a3vH2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
H	TNFRSF21	e6a3vH1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF21	ECOD (1.6)
J	TNFR_c6	e6a3vJ2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
J	TNFRSF14	e6a3vJ1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
J	TNFRSF21	e6a3vJ3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF21	ECOD (1.6)
L	TNFR_c6	e6a3vL1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
L	TNFRSF5	e6a3vL2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF5	ECOD (1.6)
L	TNFRSF14	e6a3vL3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
N	TNFR_c6	e6a3vN3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
N	TNFRSF5	e6a3vN2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF5	ECOD (1.6)
N	TNFRSF14	e6a3vN1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
P	TNFR_c6	e6a3vP1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
P	TNFRSF5	e6a3vP3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF5	ECOD (1.6)
P	TNFRSF14	e6a3vP2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
R	TNFR_c6	e6a3vR3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
R	TNFRSF14	e6a3vR1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
R	UNK_F_TYPE	e6a3vR2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: UNK_F_TYPE	ECOD (1.6)
T	TNFR_c6	e6a3vT1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
T	TNFRSF14	e6a3vT2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
T	TNFRSF21	e6a3vT3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF21	ECOD (1.6)
V	TNFR_c6	e6a3vV2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
V	TNFRSF14	e6a3vV1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
V	TNFRSF21	e6a3vV3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF21	ECOD (1.6)
X	TNFR_c6	e6a3vX2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFR_c6	ECOD (1.6)
X	TNFRSF5	e6a3vX1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF5	ECOD (1.6)
X	TNFRSF14	e6a3vX3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: TNFRSF14	ECOD (1.6)
A	TNF	e6a3vA1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
C	TNF	e6a3vC1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
E	TNF	e6a3vE1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
G	TNF	e6a3vG1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
I	TNF	e6a3vI1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
K	TNF	e6a3vK1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
M	TNF	e6a3vM1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
O	TNF	e6a3vO1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
Q	TNF	e6a3vQ1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
S	TNF	e6a3vS1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
U	TNF	e6a3vU1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
W	TNF	e6a3vW1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (utative)
D	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (utative)
F	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (utative)
H	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (utative)
J	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (utative)
L	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (utative)
N	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (utative)
P	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (utative)
T	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (utative)
V	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (utative)
X	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (utative)
A	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
C	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
E	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
G	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
I	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
K	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
M	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
O	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
Q	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
S	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
U	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
W	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	PF00020	TNFR/NGFR cysteine-rich region (TNFR_c6)	TNFR/NGFR cysteine-rich region	-	Domain
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	PF00229	TNF(Tumour Necrosis Factor) family (TNF)	TNF(Tumour Necrosis Factor) family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	Tumor necrosis factor receptor superfamily member 9	molecular transducer activity signaling receptor activity	cellular process apoptotic process cell death programmed cell death negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process biological regulation negative regulation of biological process multicellular organismal process cellular developmental process cellular process apoptotic process cell death programmed cell death negative regulation of cell population proliferation regulation of biological process cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process biological regulation negative regulation of biological process multicellular organismal process cellular developmental process regulation of leukocyte activation immature T cell proliferation in thymus regulation of cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte proliferation leukocyte activation T cell differentiation in thymus T cell activation cell differentiation lymphocyte proliferation anatomical structure development regulation of immature T cell proliferation regulation of multicellular organismal process regulation of immune system process T cell differentiation T cell proliferation regulation of lymphocyte proliferation developmental process regulation of leukocyte proliferation hemopoiesis cell activation regulation of T cell activation immature T cell proliferation regulation of immature T cell proliferation in thymus regulation of T cell proliferation mononuclear cell proliferation immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation leukocyte differentiation	cell periphery plasma membrane membrane cellular anatomical entity cell surface external side of plasma membrane side of membrane
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	Tumor necrosis factor ligand superfamily member 9	protein binding binding signaling receptor binding molecular function activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity cytokine receptor binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor binding	multicellular organismal process regulation of cellular process positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation regulation of biological process cell population proliferation multicellular organismal process regulation of cellular process positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation regulation of biological process cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process regulation of activated T cell proliferation positive regulation of biological process positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation activated T cell proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of cell-cell adhesion positive regulation of cellular process T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion biological regulation cell activation regulation of T cell activation regulation of T cell proliferation immune system process regulation of mononuclear cell proliferation cellular process regulation of lymphocyte activation response to stimulus immune response signaling cell-cell signaling cell communication regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of developmental process multicellular organism development cell differentiation anatomical structure development T cell differentiation developmental process positive regulation of cell development leukocyte differentiation cellular developmental process regulation of developmental process cell development regulation of T cell differentiation regulation of cytotoxic T cell differentiation positive regulation of hemopoiesis positive regulation of cell differentiation regulation of lymphocyte differentiation regulation of multicellular organismal development cytotoxic T cell differentiation hemopoiesis regulation of hemopoiesis positive regulation of cytotoxic T cell differentiation positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation	cell periphery plasma membrane membrane cellular anatomical entity extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR001368	TNFR/NGFR cysteine-rich region	Domain
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR020413	Tumour necrosis factor receptor 9	Family
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR034020	Tumour necrosis factor receptor 9, N-terminal	Domain
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR008983	Tumour necrosis factor-like domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR006052	Tumour necrosis factor domain	Domain
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR021184	Tumour necrosis factor, conserved site	Conserved Site
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR042373	Tumor necrosis factor ligand superfamily member 9	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	Pharos: Q07011	ulcerative colitis malignant colon neoplasm medulloblastoma tuberculosis benign colon neoplasm colorectal cancer gastric cancer hereditary diffuse gastric adenocarcinoma kidney cancer lung cancer Malignant neoplasm of kidney psoriasis cancer Crohn disease gastric neoplasm ulcerative colitis malignant colon neoplasm medulloblastoma tuberculosis benign colon neoplasm colorectal cancer gastric cancer hereditary diffuse gastric adenocarcinoma kidney cancer lung cancer Malignant neoplasm of kidney psoriasis cancer Crohn disease gastric neoplasm inflammatory bowel disease kidney neoplasm lymphatic system disease rheumatoid arthritis colonic neoplasm cutaneous lupus erythematosus hematologic disease interstitial cystitis lung adenocarcinoma
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	Pharos: P41273	contact dermatitis astrocytic tumor gastric cancer large cell medulloblastoma malignant mesothelioma ulcerative colitis gastric neoplasm lung cancer Malignant neoplasm of stomach hereditary diffuse gastric adenocarcinoma malignant ependymoma oligodendroglioma