Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AKOG1141_1ste6au2A3 A: beta barrelsX: SH3H: SH3T: SH3F: KOG1141_1stECOD (1.6)
AKOG1141_3rde6au2A1 A: beta barrelsX: SH3H: SH3T: SH3F: KOG1141_3rdECOD (1.6)
AKOG1141_2nde6au2A2 A: beta barrelsX: SH3H: SH3T: SH3F: KOG1141_2ndECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.30.30.140 Mainly Beta Roll SH3 type barrels. CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF18300Domain of unknown function (DUF5604) (DUF5604)Domain of unknown function (DUF5604)This domain is often found in the N-terminal region of proteins carrying the SET domain (Pfam:PF00856), such as the SETDB1 protein present in Homo sapiens. SETDB1 is a histone methyltransferase that suppresses gene expression and modulates heterochro ...This domain is often found in the N-terminal region of proteins carrying the SET domain (Pfam:PF00856), such as the SETDB1 protein present in Homo sapiens. SETDB1 is a histone methyltransferase that suppresses gene expression and modulates heterochromatin formation through H3K9me2/3 [1].
Domain
PF18359Histone methyltransferase Tudor domain 1 (Tudor_5)Histone methyltransferase Tudor domain 1This is the first TUDOR domain found in SETDB1 enzymes (EC:2.1.1.43) in homosapiens, also known as Eggless in Drosophila [1]. In Drosophila, SetdB1 (Egg) is important for oogenesis and the silencing of chromosome 4 [2]. SET domain, bifurcated 1 (SETD ...This is the first TUDOR domain found in SETDB1 enzymes (EC:2.1.1.43) in homosapiens, also known as Eggless in Drosophila [1]. In Drosophila, SetdB1 (Egg) is important for oogenesis and the silencing of chromosome 4 [2]. SET domain, bifurcated 1 (SETDB1) is a histone methyltransferase (HMT) that methylates lysine 9 on histone H3 (H3K9). The enzymatic activity of SETDB1, in association with MBD1-containing chromatin-associated factor 1 (MCAF1), converts H3K9me2 to H3K9me3 and represses subsequent transcription. SETDB1 is amplified in cancers such as melanoma and lung cancer, and increased expression of SETDB1 promotes tumorigenesis in a zebrafish melanoma model. In addition, SETDB1 is required for endogenous retrovirus silencing during early embryogenesis, inhibition of adipocyte differentiation, and differentiation of mesenchymal cells into osteoblasts [1]. The tandem Tudor domains in the N-terminal region are involved in protein-protein interactions [2]. The second tudor domain is Pfam:PF18385.
Domain
PF18358Histone methyltransferase Tudor domain (Tudor_4)Histone methyltransferase Tudor domainThis is a Tudor domain found in histone-lysine N-methyltransferase SETDB1 proteins (EC:2.1.1.43), also known as Eggless in Drosophila [1]. In Drosophila, SetdB1 (Egg) is important for oogenesis and the silencing of chromosome 4 [2].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Histone-lysine N-methyltransferase SETDB1