Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth F]SCOP2B SuperfamilyRas-like P-loop GTPases 8057414 3002022 SCOP2B (2022-06-29)
D [auth C]SCOP2B SuperfamilyRas-like P-loop GTPases 8057414 3002022 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth F]Rase6bcaF1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
D [auth C]Rase6bcaC1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
B [auth A]PH_13_1e6bcaA1 A: beta barrelsX: PH domain-likeH: PH domain-like (From Topology)T: PH domain-likeF: PH_13_1ECOD (1.6)
C [auth B]PH_13_1e6bcaB1 A: beta barrelsX: PH domain-likeH: PH domain-like (From Topology)T: PH domain-likeF: PH_13_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth F],
D [auth C]
PF00071Ras family (Ras)Ras familyIncludes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].
Domain
B [auth A],
C [auth B]
PF00169PH domain (PH)PH domainPH stands for pleckstrin homology.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth F],
D [auth C]
Transforming protein RhoA
B [auth A],
C [auth B]
A-kinase anchor protein 13

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A [auth F],
D [auth C]
PharosP61586
B [auth A],
C [auth B]
PharosQ12802