6F7H

Crystal structure of human AQP10

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6f7ha_	Membrane and cell surface proteins and peptides	Aquaporin-like	Aquaporin-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d6f7hb_	Membrane and cell surface proteins and peptides	Aquaporin-like	Aquaporin-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d6f7hc_	Membrane and cell surface proteins and peptides	Aquaporin-like	Aquaporin-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d6f7hd_	Membrane and cell surface proteins and peptides	Aquaporin-like	Aquaporin-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Aquaporin-like	8076108	4003025	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Aquaporin-like	8076109	3000508	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Aquaporin-like	8076109	3000508	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Aquaporin-like	8076109	3000508	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Aquaporin-like	8076109	3000508	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MIP	e6f7hA1	A: alpha complex topology	X: Aquaporin-like (From Topology)	H: Aquaporin-like (From Topology)	T: Aquaporin-like	F: MIP	ECOD (1.6)
B	MIP	e6f7hB1	A: alpha complex topology	X: Aquaporin-like (From Topology)	H: Aquaporin-like (From Topology)	T: Aquaporin-like	F: MIP	ECOD (1.6)
C	MIP	e6f7hC1	A: alpha complex topology	X: Aquaporin-like (From Topology)	H: Aquaporin-like (From Topology)	T: Aquaporin-like	F: MIP	ECOD (1.6)
D	MIP	e6f7hD1	A: alpha complex topology	X: Aquaporin-like (From Topology)	H: Aquaporin-like (From Topology)	T: Aquaporin-like	F: MIP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1080.10	Mainly Alpha	Up-down Bundle	Glycerol uptake facilitator protein	Glycerol uptake facilitator protein.	CATH (4.3.0)
B	1.20.1080.10	Mainly Alpha	Up-down Bundle	Glycerol uptake facilitator protein	Glycerol uptake facilitator protein.	CATH (4.3.0)
C	1.20.1080.10	Mainly Alpha	Up-down Bundle	Glycerol uptake facilitator protein	Glycerol uptake facilitator protein.	CATH (4.3.0)
D	1.20.1080.10	Mainly Alpha	Up-down Bundle	Glycerol uptake facilitator protein	Glycerol uptake facilitator protein.	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00230	Major intrinsic protein (MIP)	Major intrinsic protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Aquaporin-10	glycerol channel activity passive transmembrane transporter activity organic hydroxy compound transmembrane transporter activity channel activity glycerol transmembrane transporter activity transporter activity polyol transmembrane transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity urea transmembrane transporter activity amide transmembrane transporter activity water transmembrane transporter activity inorganic molecular entity transmembrane transporter activity water channel activity	transmembrane transport glycerol transmembrane transport localization transport polyol transmembrane transport carbohydrate transport cellular process organic hydroxy compound transport establishment of localization carbohydrate transmembrane transport protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis transmembrane transport glycerol transmembrane transport localization transport polyol transmembrane transport carbohydrate transport cellular process organic hydroxy compound transport establishment of localization carbohydrate transmembrane transport protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis cellular response to stimulus response to stimulus response to pH cellular response to pH response to abiotic stimulus cellular response to acidic pH cellular response to abiotic stimulus response to acidic pH cellular response to environmental stimulus fluid transport water transport response to chemical response to toxic substance	cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane lipid droplet intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle basal part of cell cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane lipid droplet intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle basal part of cell basal plasma membrane basolateral plasma membrane membrane-bounded organelle intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR026252	Aquaporin 10	Family
A, B, C, D	IPR022357	Major intrinsic protein, conserved site	Conserved Site
A, B, C, D	IPR050363	Major Intrinsic Protein/Aquaporin	Family
A, B, C, D	IPR023271	Aquaporin-like	Homologous Superfamily
A, B, C, D	IPR000425	Major intrinsic protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q96PS8	atrial fibrillation juvenile idiopathic arthritis attention deficit hyperactivity disorder, inattentive type malignant pancreatic neoplasm exocrine pancreatic carcinoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Transmembrane	Alpha-helical polytopic	Major Intrinsic Protein (MIP)/FNT superfamily	Major intrinsic protein (MIP) family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Aquaporins and Glyceroporins	AQP10 aquaglyceroporin

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.