Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyProtein kinase-like (PK-like) 8040310 3000066 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyProtein kinase-like (PK-like) 8040310 3000066 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APkinase_Tyre6gueA1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
BCyclin_Ce6gueB1 A: alpha arraysX: HTHH: HTHT: Cyclin-likeF: Cyclin_CECOD (1.6)
BCyclin_Ne6gueB2 A: alpha arraysX: HTHH: HTHT: Cyclin-likeF: Cyclin_NECOD (1.6)
DCyclin_Ce6gueD2 A: alpha arraysX: HTHH: HTHT: Cyclin-likeF: Cyclin_CECOD (1.6)
DCyclin_Ne6gueD1 A: alpha arraysX: HTHH: HTHT: Cyclin-likeF: Cyclin_NECOD (1.6)
CPkinase_Tyre6gueC1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
A1.10.510.10 Mainly Alpha Orthogonal Bundle Transferase(Phosphotransferase) domain 1CATH (4.3.0)
B1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A domain 1CATH (4.3.0)
D1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A domain 1CATH (4.3.0)
C3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
C1.10.510.10 Mainly Alpha Orthogonal Bundle Transferase(Phosphotransferase) domain 1CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00069Protein kinase domain (Pkinase)Protein kinase domain- Domain
B, D
PF02984Cyclin, C-terminal domain (Cyclin_C)Cyclin, C-terminal domainCyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.Domain
B, D
PF00134Cyclin, N-terminal domain (Cyclin_N)Cyclin, N-terminal domainCyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.Domain
PF00069Protein kinase domain (Pkinase)Protein kinase domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Cyclin-dependent kinase 2
B, D
Cyclin-A2
Cyclin-dependent kinase 2

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP24941
PharosP24941

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
TPO Parent Component: THR

RESIDAA0038

PSI-MOD :  O-phospho-L-threonine MOD:00047
TPO Parent Component: THR

RESIDAA0038 , AA0038

PSI-MOD :  O-phospho-L-threonine MOD:00047 , O-phospho-L-threonine MOD:00047