6NCF

The structure of Stable-5-Lipoxygenase bound to AKBA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d6ncfc2	All alpha proteins	Lipoxigenase	Lipoxigenase	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d6ncfc1	All beta proteins	Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipase/lipooxygenase domain (PLAT/LH2 domain)	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d6ncfd2	All alpha proteins	Lipoxigenase	Lipoxigenase	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d6ncfd1	All beta proteins	Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipase/lipooxygenase domain (PLAT/LH2 domain)	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Lipoxygenase	8098328	3001410	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Lipase/lipooxygenase domain (PLAT/LH2 domain)	8101094	3001168	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Lipoxygenase	8098328	3001410	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Lipase/lipooxygenase domain (PLAT/LH2 domain)	8101094	3001168	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lipase/lipooxygenase domain (PLAT/LH2 domain)	8101094	3001168	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lipoxygenase	8098328	3001410	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Lipoxygenase	8098328	3001410	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Lipase/lipooxygenase domain (PLAT/LH2 domain)	8101094	3001168	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PLAT,RNAse_Pc_like	e6ncfA1	A: beta sandwiches	X: jelly-roll	H: Lipase/lipooxygenase domain (PLAT/LH2 domain) (From Topology)	T: Lipase/lipooxygenase domain (PLAT/LH2 domain)	F: PLAT,RNAse_Pc_like	ECOD (1.6)
A	Lipoxygenase	e6ncfA2	A: alpha bundles	X: Lipoxygenase (From Topology)	H: Lipoxygenase (From Topology)	T: Lipoxygenase	F: Lipoxygenase	ECOD (1.6)
C	PLAT	e6ncfC1	A: beta sandwiches	X: jelly-roll	H: Lipase/lipooxygenase domain (PLAT/LH2 domain) (From Topology)	T: Lipase/lipooxygenase domain (PLAT/LH2 domain)	F: PLAT	ECOD (1.6)
C	Lipoxygenase	e6ncfC2	A: alpha bundles	X: Lipoxygenase (From Topology)	H: Lipoxygenase (From Topology)	T: Lipoxygenase	F: Lipoxygenase	ECOD (1.6)
B	PLAT,RNAse_Pc_like	e6ncfB1	A: beta sandwiches	X: jelly-roll	H: Lipase/lipooxygenase domain (PLAT/LH2 domain) (From Topology)	T: Lipase/lipooxygenase domain (PLAT/LH2 domain)	F: PLAT,RNAse_Pc_like	ECOD (1.6)
B	Lipoxygenase	e6ncfB2	A: alpha bundles	X: Lipoxygenase (From Topology)	H: Lipoxygenase (From Topology)	T: Lipoxygenase	F: Lipoxygenase	ECOD (1.6)
D	PLAT	e6ncfD1	A: beta sandwiches	X: jelly-roll	H: Lipase/lipooxygenase domain (PLAT/LH2 domain) (From Topology)	T: Lipase/lipooxygenase domain (PLAT/LH2 domain)	F: PLAT	ECOD (1.6)
D	Lipoxygenase	e6ncfD2	A: alpha bundles	X: Lipoxygenase (From Topology)	H: Lipoxygenase (From Topology)	T: Lipoxygenase	F: Lipoxygenase	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00305	Lipoxygenase (Lipoxygenase)	Lipoxygenase	-	Domain
A, B, C, D	PF01477	PLAT/LH2 domain (PLAT)	PLAT/LH2 domain	This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain bind ...	This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase Pfam:PF01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Arachidonate 5-lipoxygenase	hydrolase activity catalytic activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen arachidonate 8(S)-lipoxygenase activity dioxygenase activity cation binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding hydrolase activity catalytic activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen arachidonate 8(S)-lipoxygenase activity dioxygenase activity cation binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding arachidonate 5-lipoxygenase activity arachidonate 12(S)-lipoxygenase activity	regulation of biological process regulation of cellular process positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte adhesion to vascular endothelial cell regulation of leukocyte adhesion to vascular endothelial cell positive regulation of leukocyte adhesion to arterial endothelial cell leukocyte cell-cell adhesion positive regulation of cell-cell adhesion regulation of leukocyte adhesion to arterial endothelial cell cell adhesion cell-cell adhesion regulation of biological process regulation of cellular process positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte adhesion to vascular endothelial cell regulation of leukocyte adhesion to vascular endothelial cell positive regulation of leukocyte adhesion to arterial endothelial cell leukocyte cell-cell adhesion positive regulation of cell-cell adhesion regulation of leukocyte adhesion to arterial endothelial cell cell adhesion cell-cell adhesion leukocyte adhesion to vascular endothelial cell leukocyte adhesion to arterial endothelial cell regulation of leukocyte cell-cell adhesion cellular process regulation of cell-cell adhesion positive regulation of cellular process dendritic cell migration leukocyte migration immune system process mononuclear cell migration cell migration cell motility wound healing response to stimulus regulation of response to external stimulus negative regulation of response to stimulus negative regulation of wound healing negative regulation of biological process response to external stimulus negative regulation of response to wounding regulation of response to wounding regulation of response to stimulus response to stress regulation of response to stress negative regulation of response to external stimulus regulation of wound healing response to wounding multicellular organismal process regulation of developmental process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process multicellular organism development positive regulation of biomineral tissue development ossification anatomical structure development biomineral tissue development regulation of multicellular organismal process developmental process regulation of multicellular organismal development bone mineralization animal organ development tissue development positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification regulation of defense response regulation of inflammatory response to wounding defense response regulation of inflammatory response inflammatory response to wounding inflammatory response leukocyte migration involved in inflammatory response production of molecular mediator involved in inflammatory response arachidonate metabolite production involved in inflammatory response leukotriene production involved in inflammatory response protein localization regulation of localization establishment of protein localization nitrogen compound transport cell communication localization cellular macromolecule localization regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region protein secretion establishment of localization regulation of protein secretion regulation of secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport signaling hormone secretion protein localization to extracellular region peptide secretion secretion by cell regulation of secretion by cell amide transport signal release regulation of signaling secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization cell-cell signaling export from cell regulation of protein transport peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport regulation of cell communication insulin secretion cell chemotaxis cellular response to stimulus leukocyte chemotaxis involved in inflammatory response chemotaxis cellular response to chemical stimulus taxis response to chemical leukocyte chemotaxis locomotion fat cell differentiation cellular developmental process regulation of cell differentiation cell differentiation regulation of fat cell differentiation icosanoid metabolic process fatty acid metabolic process long-chain fatty acid metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process arachidonate metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process olefinic compound metabolic process metabolic process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process reactive oxygen species biosynthetic process regulation of biosynthetic process reactive oxygen species metabolic process regulation of reactive oxygen species biosynthetic process biosynthetic process regulation of metabolic process regulation of reactive oxygen species metabolic process leukotriene metabolic process chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis lipoxin metabolic process lipoxin biosynthetic process lipid biosynthetic process fatty acid derivative biosynthetic process fatty acid derivative metabolic process small molecule biosynthetic process leukotriene biosynthetic process organic acid biosynthetic process carboxylic acid biosynthetic process icosanoid biosynthetic process lipoxygenase pathway regulation of sprouting angiogenesis angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development system development blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis sprouting angiogenesis vasculature development circulatory system development anatomical structure morphogenesis negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis negative regulation of multicellular organismal process negative regulation of sprouting angiogenesis humoral immune response immune response cellular response to oxidative stress regulation of cellular response to stress cellular response to chemical stress regulation of cellular response to oxidative stress response to oxidative stress cellular response to stress regulation of response to oxidative stress negative regulation of inflammatory response negative regulation of defense response ether metabolic process long-chain fatty acid biosynthetic process epoxide metabolic process ether biosynthetic process monocarboxylic acid biosynthetic process fatty acid biosynthetic process leukotriene A4 metabolic process leukotriene A4 biosynthetic process vascular wound healing angiogenesis involved in wound healing negative regulation of vascular wound healing regulation of vascular wound healing regulation of cytokine production involved in inflammatory response cytokine production regulation of cytokine production regulation of macromolecule metabolic process cytokine production involved in inflammatory response gene expression macromolecule biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of response to endoplasmic reticulum stress regulation of response to endoplasmic reticulum stress negative regulation of cellular process response to endoplasmic reticulum stress lipid modification lipid oxidation negative regulation of cell population proliferation cell population proliferation endothelial cell proliferation negative regulation of endothelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation	membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane cytoplasm membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system nuclear membrane membrane organelle membrane cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen organelle envelope lumen organelle lumen nuclear envelope lumen perinuclear region of cytoplasm extracellular region extracellular space nuclear periphery nuclear lumen nuclear matrix intracellular vesicle ficolin-1-rich granule cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle vesicle nucleoplasm vesicle lumen cytoplasmic vesicle lumen secretory granule lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR020834	Lipoxygenase, conserved site	Conserved Site
A, B, C, D	IPR001885	Lipoxygenase, mammalian	Family
A, B, C, D	IPR013819	Lipoxygenase, C-terminal	Domain
A, B, C, D	IPR001024	PLAT/LH2 domain	Domain
A, B, C, D	IPR042062	Lipoxygenase, vertebrates, PLAT domain	Domain
A, B, C, D	IPR036392	PLAT/LH2 domain superfamily	Homologous Superfamily
A, B, C, D	IPR036226	Lipoxigenase, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR000907	Lipoxygenase	Family
A, B, C, D	IPR020833	Lipoxygenase, iron binding site	Binding Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P09917	rheumatoid arthritis chronic myelogenous leukemia, BCR-ABL1 positive asthma malignant colon neoplasm ulcerative colitis microcystic adenoma follicular thyroid adenoma adenoma Neoplasm Invasiveness atherosclerosis pulmonary hypertension colitis urticaria middle cerebral artery infarction papillary adenoma rheumatoid arthritis chronic myelogenous leukemia, BCR-ABL1 positive asthma malignant colon neoplasm ulcerative colitis microcystic adenoma follicular thyroid adenoma adenoma Neoplasm Invasiveness atherosclerosis pulmonary hypertension colitis urticaria middle cerebral artery infarction papillary adenoma colonic neoplasm Sjogren syndrome dermatomyositis gallbladder disease glioblastoma osteoarthritis inherited susceptibility to asthma invasive ductal breast carcinoma periodontitis chronic kidney disease large cell medulloblastoma psoriasis lung cancer medulloblastoma endometriosis gastric cancer multiple organ dysfunction syndrome hereditary diffuse gastric adenocarcinoma adrenal cortex carcinoma osteosarcoma arteriosclerosis disorder astrocytic tumor interstitial cystitis pancreatic ductal adenocarcinoma benign colon neoplasm ischemia reperfusion injury pilocytic astrocytoma lung carcinoma cystic fibrosis MALT lymphoma gastric neoplasm non-small cell lung carcinoma allergic asthma ovarian cancer intrinsic asthma breast cancer juvenile idiopathic arthritis polyp of colon lung adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.