Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6pf8a1 Alpha and beta proteins (a/b) Dihydrofolate reductase-like Dihydrofolate reductase-like Dihydrofolate reductases Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Ad6pf8a2 Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Bd6pf8b1 Alpha and beta proteins (a/b) Dihydrofolate reductase-like Dihydrofolate reductase-like Dihydrofolate reductases Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Bd6pf8b2 Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Cd6pf8c1 Alpha and beta proteins (a/b) Dihydrofolate reductase-like Dihydrofolate reductase-like Dihydrofolate reductases Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Cd6pf8c2 Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Dd6pf8d1 Alpha and beta proteins (a/b) Dihydrofolate reductase-like Dihydrofolate reductase-like Dihydrofolate reductases Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Dd6pf8d2 Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Ed6pf8e1 Alpha and beta proteins (a/b) Dihydrofolate reductase-like Dihydrofolate reductase-like Dihydrofolate reductases Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Ed6pf8e2 Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AThymidylat_synte6pf8A1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
ADHFR_1e6pf8A2 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)
BThymidylat_synte6pf8B2 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
BDHFR_1e6pf8B1 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)
CThymidylat_synte6pf8C1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
CDHFR_1e6pf8C2 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)
DThymidylat_synte6pf8D1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
DDHFR_1e6pf8D2 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)
EThymidylat_synte6pf8E1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
EDHFR_1e6pf8E2 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00303Thymidylate synthase (Thymidylat_synt)Thymidylate synthaseThis is a family of proteins that are flavin-dependent thymidylate synthases.Domain
A, B, C, D, E
PF00186Dihydrofolate reductase (DHFR_1)Dihydrofolate reductase- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Bifunctional dihydrofolate reductase-thymidylate synthase