6SQ3
Crystal structure of mouse PRMT6 in complex with inhibitor U1
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d6sq3a_ | Alpha and beta proteins (a/b) | S-adenosyl-L-methionine-dependent methyltransferases | S-adenosyl-L-methionine-dependent methyltransferases | automated matches | automated matches | House mouse (Mus musculus ) [TaxId: 10090 ], | SCOPe (2.08) |
B | d6sq3b_ | Alpha and beta proteins (a/b) | S-adenosyl-L-methionine-dependent methyltransferases | S-adenosyl-L-methionine-dependent methyltransferases | automated matches | automated matches | House mouse (Mus musculus ) [TaxId: 10090 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PRMT5_C_1 | e6sq3A2 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PRMT5_C_1 | ECOD (1.6) |
A | PrmA | e6sq3A1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PrmA | ECOD (1.6) |
B | PRMT5_C_1 | e6sq3B2 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PRMT5_C_1 | ECOD (1.6) |
B | PrmA | e6sq3B1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PrmA | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF13649 | Methyltransferase domain (Methyltransf_25) | Methyltransferase domain | This family appears to be a methyltransferase domain. | Domain | |
PF22528 | Arginine methyltransferase oligomerization subdomain (PRMT_C) | Arginine methyltransferase oligomerization subdomain | This entry represents a domain found C-terminal in protein arginine methyltransferases. This domain is involved in oligomerisation. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR025799 | Protein arginine N-methyltransferase | Family | |
IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Homologous Superfamily | |
IPR041698 | Methyltransferase domain 25 | Domain |