Crystal structure of mouse PRMT6 in complex with inhibitors
Bonnefond, L., Cavarelli, J.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Protein arginine N-methyltransferase 6 | 386 | Mus musculus | Mutation(s): 1  Gene Names: Prmt6, Hrmt1l6 EC: 2.1.1.319 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q6NZB1 (Mus musculus) Explore Q6NZB1  Go to UniProtKB:  Q6NZB1 | |||||
IMPC:  MGI:2139971 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q6NZB1 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 1 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
6RE (Subject of Investigation/LOI) Query on 6RE | C [auth A], D [auth B] | [[2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethylamino]-azanyl-methylidene]azanium C12 H19 N8 O3 OIGRVZYOOMUALG-IOSLPCCCSA-O |
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 41.526 | α = 90 |
b = 117.979 | β = 103.3 |
c = 71.945 | γ = 90 |
Software Name | Purpose |
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PHENIX | refinement |
PDB_EXTRACT | data extraction |
XDS | data reduction |
XDS | data scaling |
PHASER | phasing |