6V2C
Complex of mutant (K162M) of E. coli L-asparaginase II with L-Asp. Covalent acyl-enzyme intermediate and tetrahedral intermediate
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Glutaminase/Asparaginase | 8033474 | 3001625 | SCOP2B (2022-06-29) |
B [auth C] | SCOP2B Superfamily | Glutaminase/Asparaginase | 8033474 | 3001625 | SCOP2B (2022-06-29) |
C [auth B] | SCOP2B Superfamily | Glutaminase/Asparaginase | 8033474 | 3001625 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Glutaminase/Asparaginase | 8033474 | 3001625 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PRK04183 | e6v2cA1 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase C-terminal domain (From Topology) | H: Glutaminase/Asparaginase C-terminal domain (From Topology) | T: Glutaminase/Asparaginase C-terminal domain | F: PRK04183 | ECOD (1.6) |
A | Asparaginase | e6v2cA2 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase N-terminal domain (From Topology) | H: Glutaminase/Asparaginase N-terminal domain (From Topology) | T: Glutaminase/Asparaginase N-terminal domain | F: Asparaginase | ECOD (1.6) |
B [auth C] | PRK04183 | e6v2cC1 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase C-terminal domain (From Topology) | H: Glutaminase/Asparaginase C-terminal domain (From Topology) | T: Glutaminase/Asparaginase C-terminal domain | F: PRK04183 | ECOD (1.6) |
B [auth C] | Asparaginase | e6v2cC2 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase N-terminal domain (From Topology) | H: Glutaminase/Asparaginase N-terminal domain (From Topology) | T: Glutaminase/Asparaginase N-terminal domain | F: Asparaginase | ECOD (1.6) |
C [auth B] | PRK04183 | e6v2cB2 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase C-terminal domain (From Topology) | H: Glutaminase/Asparaginase C-terminal domain (From Topology) | T: Glutaminase/Asparaginase C-terminal domain | F: PRK04183 | ECOD (1.6) |
C [auth B] | Asparaginase | e6v2cB1 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase N-terminal domain (From Topology) | H: Glutaminase/Asparaginase N-terminal domain (From Topology) | T: Glutaminase/Asparaginase N-terminal domain | F: Asparaginase | ECOD (1.6) |
D | PRK04183 | e6v2cD2 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase C-terminal domain (From Topology) | H: Glutaminase/Asparaginase C-terminal domain (From Topology) | T: Glutaminase/Asparaginase C-terminal domain | F: PRK04183 | ECOD (1.6) |
D | Asparaginase | e6v2cD1 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase N-terminal domain (From Topology) | H: Glutaminase/Asparaginase N-terminal domain (From Topology) | T: Glutaminase/Asparaginase N-terminal domain | F: Asparaginase | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A, B [auth C], C [auth B], D | PF00710 | Asparaginase, N-terminal (Asparaginase) | Asparaginase, N-terminal | This is the N-terminal domain of this enzyme. | Domain |
A, B [auth C], C [auth B], D | PF17763 | Glutaminase/Asparaginase C-terminal domain (Asparaginase_C) | Glutaminase/Asparaginase C-terminal domain | This domain is found at the C-terminus of asparaginase enzymes. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A, B [auth C], C [auth B], D | IPR027473 | L-asparaginase, C-terminal | Homologous Superfamily |
A, B [auth C], C [auth B], D | IPR027475 | Asparaginase/glutaminase, active site 2 | Active Site |
A, B [auth C], C [auth B], D | IPR036152 | Asparaginase/glutaminase-like superfamily | Homologous Superfamily |
A, B [auth C], C [auth B], D | IPR020827 | Asparaginase/glutaminase, active site 1 | Active Site |
A, B [auth C], C [auth B], D | IPR037152 | L-asparaginase, N-terminal domain superfamily | Homologous Superfamily |
A, B [auth C], C [auth B], D | IPR040919 | Asparaginase/glutaminase, C-terminal | Domain |
A, B [auth C], C [auth B], D | IPR027474 | L-asparaginase, N-terminal | Domain |
A, B [auth C], C [auth B], D | IPR004550 | L-asparaginase, type II | Family |
A, B [auth C], C [auth B], D | IPR006034 | Asparaginase/glutaminase-like | Family |
Protein Modification Annotation
Modified Residue(s) | ||
---|---|---|
Chain | Residue(s) | Description |
A, B [auth C], C [auth B], D | AEI | Parent Component: THR :  AA0525 :  O-(L-isoaspartyl)-L-threonine (active site intermediate) MOD:01671 , O-(L-isoaspartyl)-L-threonine (cross-link) MOD:01947 |
A, B [auth C], C [auth B], D | QNY | Parent Component: Thr :  AA0525 |