Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth B]SCOP2B SuperfamilyProtein kinase-like (PK-like) 8069247 3000066 SCOP2B (2022-06-29)
B [auth A]SCOP2B SuperfamilyProtein kinase-like (PK-like) 8069247 3000066 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth B]Pkinase_Tyre6vnjB1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
B [auth A]Pkinase_Tyre6vnjA1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth B],
B [auth A]
PF07714Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)Protein tyrosine and serine/threonine kinaseProtein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosph ...Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [1]; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth B],
B [auth A]
Tyrosine-protein kinase JAK2

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth B],
B [auth A]
IPR020635Tyrosine-protein kinase, catalytic domainDomain
A [auth B],
B [auth A]
IPR000719Protein kinase domainDomain
A [auth B],
B [auth A]
IPR041381JAK1-3/TYK2, pleckstrin homology-like domainDomain
A [auth B],
B [auth A]
IPR017441Protein kinase, ATP binding siteBinding Site
A [auth B],
B [auth A]
IPR036860SH2 domain superfamilyHomologous Superfamily
A [auth B],
B [auth A]
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainDomain
A [auth B],
B [auth A]
IPR051286Janus Kinase (JAK)Family
A [auth B],
B [auth A]
IPR041046JAK, FERM F2 lobe domainDomain
A [auth B],
B [auth A]
IPR019749Band 4.1 domainDomain
A [auth B],
B [auth A]
IPR020693Tyrosine-protein kinase, non-receptor Jak2Family
A [auth B],
B [auth A]
IPR035860Tyrosine-protein kinase JAK2, SH2 domainDomain
A [auth B],
B [auth A]
IPR037838JAK2, FERM domain C-lobeDomain
A [auth B],
B [auth A]
IPR000299FERM domainDomain
A [auth B],
B [auth A]
IPR016251Tyrosine-protein kinase, non-receptor Jak/Tyk2Family
A [auth B],
B [auth A]
IPR008266Tyrosine-protein kinase, active siteActive Site
A [auth B],
B [auth A]
IPR019748FERM central domainDomain
A [auth B],
B [auth A]
IPR035963FERM superfamily, second domainHomologous Superfamily
A [auth B],
B [auth A]
IPR000980SH2 domainDomain
A [auth B],
B [auth A]
IPR011993PH-like domain superfamilyHomologous Superfamily
A [auth B],
B [auth A]
IPR035588Janus kinase 2, pseudokinase domainDomain
A [auth B],
B [auth A]
IPR035589Janus kinase 2, catalytic domainDomain
A [auth B],
B [auth A]
IPR011009Protein kinase-like domain superfamilyHomologous Superfamily
A [auth B],
B [auth A]
IPR041155FERM F1 lobe ubiquitin-like domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A [auth B],
B [auth A]
PharosO60674

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A [auth B],
B [auth A]
PTR Parent Component: TYR

RESIDAA0039

PSI-MOD :  O4'-phospho-L-tyrosine MOD:00048