7QFA

Monoclinic crystal structure of PTG CBM21 in complex with beta-cyclodextrin

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CBM_21	e7qfaA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: CBM_21	ECOD (1.6)
B	CBM_21	e7qfaB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: CBM_21	ECOD (1.6)
C	CBM_21	e7qfaC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: CBM_21	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF03370	Carbohydrate/starch-binding module (family 21) (CBM_21)	Carbohydrate/starch-binding module (family 21)	This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolism. For instance, the mouse PTG protein Swiss:O08541 has been shown to interact with glycogen synthase, phosphorylase kinase, ph ...	This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolism. For instance, the mouse PTG protein Swiss:O08541 has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolism. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localises it to glycogen. Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolism. This family is a carbohydrate binding domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Protein phosphatase 1 regulatory subunit 3C	protein phosphatase binding phosphatase binding protein phosphatase 1 binding protein binding binding enzyme binding polysaccharide binding carbohydrate binding glycogen binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein phosphatase binding phosphatase binding protein phosphatase 1 binding protein binding binding enzyme binding polysaccharide binding carbohydrate binding glycogen binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity molecular adaptor activity	regulation of glycogen biosynthetic process regulation of cellular process glucan biosynthetic process energy derivation by oxidation of organic compounds cellular biosynthetic process regulation of glucan biosynthetic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process regulation of primary metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process regulation of biosynthetic process carbohydrate metabolic process regulation of glycogen biosynthetic process regulation of cellular process glucan biosynthetic process energy derivation by oxidation of organic compounds cellular biosynthetic process regulation of glucan biosynthetic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process regulation of primary metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process regulation of biosynthetic process carbohydrate metabolic process regulation of biological process polysaccharide biosynthetic process carbohydrate biosynthetic process cellular metabolic process glycogen metabolic process biological regulation primary metabolic process regulation of cellular metabolic process generation of precursor metabolites and energy regulation of macromolecule metabolic process glycogen biosynthetic process macromolecule biosynthetic process regulation of cellular biosynthetic process biosynthetic process regulation of polysaccharide biosynthetic process metabolic process cellular process energy reserve metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of carbohydrate biosynthetic process regulation of glycogen metabolic process regulation of metabolic process	phosphatase complex protein-containing complex protein phosphatase type 1 complex intracellular anatomical structure catalytic complex cytoplasm cellular anatomical entity protein serine/threonine phosphatase complex cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR050782	Protein phosphatase 1 regulatory subunit 3	Family
A, B, C	IPR038175	CBM21 domain superfamily	Homologous Superfamily
A, B, C	IPR017434	Protein phosphatase 1 regulatory subunit 3B/C/D, metazoa	Family
A, B, C	IPR005036	CBM21 (carbohydrate binding type-21) domain	Domain
A, B, C	IPR030683	Protein phosphatase 1 regulatory subunit 3C	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q9UQK1	Liver Cirrhosis, Experimental primitive neuroectodermal tumor astrocytic tumor esophageal adenocarcinoma large cell medulloblastoma lung cancer malignant glioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis atypical teratoid rhabdoid tumor glioblastoma malignant colon neoplasm malignant mesothelioma pancreatic ductal adenocarcinoma Liver Cirrhosis, Experimental primitive neuroectodermal tumor astrocytic tumor esophageal adenocarcinoma large cell medulloblastoma lung cancer malignant glioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis atypical teratoid rhabdoid tumor glioblastoma malignant colon neoplasm malignant mesothelioma pancreatic ductal adenocarcinoma pilocytic astrocytoma breast cancer interstitial cystitis lung adenocarcinoma malignant ependymoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.