Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF13391HNH endonuclease (HNH_2)HNH endonuclease- Domain
A, B, C, D
PF18145SMODS-associated and fused to various effectors sensor domain (SAVED)SMODS-associated and fused to various effectors sensor domainPredicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains [1]. This domain has been characterised in CD-NTase-associated protein 4 (Cap4), the founding member of ...Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains [1]. This domain has been characterised in CD-NTase-associated protein 4 (Cap4), the founding member of a major family of downstream receptors that specifically respond to nucleotide second messenger signals in CBASS immunity, a bacterial system that provides immunity against bacteriophage [2,3]. SAVED exhibits divergence in its nucleotide binding pocket which enables the recognition of a wide range of CD-NTase products such as bacterial second messengers with alternative ring size, nucleobase, and 3'-5' or 2'-5' phosphodiester linkages [2]. The sensing of ligands by SAVED activates effectors that are essential for CBASS-mediated protection of bacteria from phage infection.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage