Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyTrypsin-like serine proteases 8076467 3000114 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APeptidase_C30_Ne7t40A1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrelF: Peptidase_C30_NECOD (1.6)
APeptidase_C30_Ce7t40A2 A: alpha arraysX: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)H: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)T: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainF: Peptidase_C30_CECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF05409Coronavirus endopeptidase C30 (Peptidase_C30)Coronavirus endopeptidase C30- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
3C-like proteinase

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR022733DPUP/SUD, C-terminal, betacoronavirusDomain
IPR043611Coronavirus replicase NSP3, C-terminalDomain
IPR038123Non-structural protein NSP4, C-terminal superfamily, coronavirusHomologous Superfamily
IPR042570Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirusHomologous Superfamily
IPR047566Coronavirus replicase NSP3, Y domainDomain
IPR043178Papain-like protease, thumb domain superfamily, coronavirusHomologous Superfamily
IPR044388Non-structural protein 2, MERS-CoV-likeDomain
IPR043612Non-structural protein NSP4, N-terminal, coronavirusDomain
IPR044353NSP3, second ubiquitin-like (Ubl) domain, coronavirusDomain
IPR009003Peptidase S1, PA clanHomologous Superfamily
IPR044382NSP3, SUD-C domain, MERS-CoV-likeDomain
IPR013016Peptidase C16, coronavirusDomain
IPR037204Non-structural protein NSP7 superfamily, coronavirusHomologous Superfamily
IPR044357NSP3, first ubiquitin-like (Ubl) domain, coronavirusDomain
IPR046443NSP1, globular domain, alpha/betacoronavirusDomain
IPR043610Non-structural protein 6, coronavirusDomain
IPR043477Peptidase C30, domain 3, coronavirusHomologous Superfamily
IPR018995RNA synthesis protein NSP10, coronavirusDomain
IPR038400Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirusHomologous Superfamily
IPR046442NSP1, C-terminal domain, betacoronavirusDomain
IPR043615Nonstructural protein 2, N-terminal domain, coronavirusDomain
IPR043177Papain-like protease, N-terminal domain superfamily, coronavirusHomologous Superfamily
IPR014822Non-structural protein NSP9, coronavirusDomain
IPR021590NSP1, globular domain, betacoronavirusDomain
IPR024375Non-structural protein NSP3, SUD-M domain, betacoronavirusDomain
IPR044367Non-structural protein 6, betacoronavirusDomain
IPR037230Non-structural protein NSP8 superfamily, coronavirusHomologous Superfamily
IPR014828Non-structural protein NSP7, coronavirusDomain
IPR032505Non-structural protein NSP4, C-terminal, coronavirusDomain
IPR043503Papain-like viral protease, palm and finger domains, coronavirusHomologous Superfamily
IPR014829Non-structural protein NSP8, coronavirusDomain
IPR036499Non-structural protein NSP9 superfamily, coronavirusHomologous Superfamily
IPR002589Macro domainDomain
IPR047567Non-structural protein NSP3, group 2-specific marker domain, betacoronavirusDomain
IPR008740Peptidase C30, coronavirusDomain
IPR036333RNA synthesis protein NSP10 superfamily, coronavirusHomologous Superfamily
IPR047573Non-structural protein 2, middle domain, coronavirusDomain
IPR049894Coronavirus NSP3, 3Ecto domainDomain
IPR043472Macro domain-likeHomologous Superfamily
IPR044371Non-structural protein 3, X-domain-likeDomain
IPR032592Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirusDomain
IPR043613Non-structural protein 2, C-terminal domain, coronavirusDomain
IPR038083Non-structural protein NSP3A domain-like superfamilyHomologous Superfamily
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily