7W2H

A double cysteine variant of the sigma-1 receptor from Xenopus laevis complexed with S1RA

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ERG2_Sigma1R	e7w2hA1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
A	F_UNCLASSIFIED	e7w2hA2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth C]	ERG2_Sigma1R	e7w2hC1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
B [auth C]	F_UNCLASSIFIED	e7w2hC2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth E]	ERG2_Sigma1R	e7w2hE1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
D [auth B]	ERG2_Sigma1R	e7w2hB1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
D [auth B]	F_UNCLASSIFIED	e7w2hB2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth D]	ERG2_Sigma1R	e7w2hD1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
E [auth D]	F_UNCLASSIFIED	e7w2hD2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
F	ERG2_Sigma1R	e7w2hF1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
G	ERG2_Sigma1R	e7w2hG1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
G	F_UNCLASSIFIED	e7w2hG2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
H	ERG2_Sigma1R	e7w2hH1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
H	F_UNCLASSIFIED	e7w2hH2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
I	ERG2_Sigma1R	e7w2hI1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
J	ERG2_Sigma1R	e7w2hJ1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
J	F_UNCLASSIFIED	e7w2hJ2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
K	ERG2_Sigma1R	e7w2hK1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
K	F_UNCLASSIFIED	e7w2hK2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
L	ERG2_Sigma1R	e7w2hL1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
M	ERG2_Sigma1R	e7w2hM1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
N	ERG2_Sigma1R	e7w2hN1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
O	ERG2_Sigma1R	e7w2hO1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
O	F_UNCLASSIFIED	e7w2hO2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
P	ERG2_Sigma1R	e7w2hP1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
Q	ERG2_Sigma1R	e7w2hQ1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
Q	F_UNCLASSIFIED	e7w2hQ2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
R	ERG2_Sigma1R	e7w2hR1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
R	F_UNCLASSIFIED	e7w2hR2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
S	ERG2_Sigma1R	e7w2hS1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
T	ERG2_Sigma1R	e7w2hT1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
T	F_UNCLASSIFIED	e7w2hT2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
U	ERG2_Sigma1R	e7w2hU1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
U	F_UNCLASSIFIED	e7w2hU2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
V	ERG2_Sigma1R	e7w2hV1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
W	ERG2_Sigma1R	e7w2hW1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
W	F_UNCLASSIFIED	e7w2hW2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)
X	ERG2_Sigma1R	e7w2hX1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: ERG2_Sigma1R	ECOD (1.6)
X	F_UNCLASSIFIED	e7w2hX2	A: extended segments	X: Transmembrane helix of sigma-1 receptor (From Topology)	H: Transmembrane helix of sigma-1 receptor (From Topology)	T: Transmembrane helix of sigma-1 receptor	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C], C [auth E], D [auth B], E [auth D], A, B [auth C], C [auth E], D [auth B], E [auth D], F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	PF04622	ERG2 and Sigma1 receptor like protein (ERG2_Sigma1R)	ERG2 and Sigma1 receptor like protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth E], D [auth B], E [auth D], A, B [auth C], C [auth E], D [auth B], E [auth D], F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	Sigma non-opioid intracellular receptor 1	-	organic hydroxy compound metabolic process steroid metabolic process sterol metabolic process lipid biosynthetic process alcohol metabolic process ergosterol biosynthetic process cellular lipid biosynthetic process small molecule metabolic process ergosterol metabolic process steroid biosynthetic process phytosteroid metabolic process secondary alcohol biosynthetic process small molecule biosynthetic process cellular metabolic process organic hydroxy compound metabolic process steroid metabolic process sterol metabolic process lipid biosynthetic process alcohol metabolic process ergosterol biosynthetic process cellular lipid biosynthetic process small molecule metabolic process ergosterol metabolic process steroid biosynthetic process phytosteroid metabolic process secondary alcohol biosynthetic process small molecule biosynthetic process cellular metabolic process primary metabolic process phytosteroid biosynthetic process secondary alcohol metabolic process biosynthetic process sterol biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process cellular lipid metabolic process metabolic process cellular process lipid metabolic process localization transport macromolecule localization lipid localization lipid transport establishment of localization	membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle vesicle organelle inner membrane nuclear membrane membrane nucleus membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle vesicle organelle inner membrane nuclear membrane membrane nucleus endomembrane system organelle envelope nuclear inner membrane nuclear envelope organelle membrane nuclear outer membrane organelle outer membrane bounding membrane of organelle nuclear outer membrane-endoplasmic reticulum membrane network outer membrane organelle subcompartment endoplasmic reticulum subcompartment endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth E], D [auth B], E [auth D], A, B [auth C], C [auth E], D [auth B], E [auth D], F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR006716	ERG2/sigma1 receptor-like	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B [auth C], C [auth E], D [auth B], E [auth D] A, B [auth C], C [auth E], D [auth B], E [auth D], F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	OPM				ERG2 and Sigma1 receptor family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth C], C [auth E], D [auth B], E [auth D] A, B [auth C], C [auth E], D [auth B], E [auth D], F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B [auth C], C [auth E], D [auth B], E [auth D] A, B [auth C], C [auth E], D [auth B], E [auth D], F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Novel Receptors	Sigma-1 (σ₁) receptor, closed conformation