8C9U

Crystal structure of SARS-CoV-2 Mpro-Q189K mutant in complex with nirmatrelvir


Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth AAA]PF05409Coronavirus endopeptidase C30 (Peptidase_C30)Coronavirus endopeptidase C30- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth AAA]Non-structural protein 11

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth AAA]IPR022733DPUP/SUD, C-terminal, betacoronavirusDomain
A [auth AAA]IPR024358Non-structural protein NSP3, N-terminal, betacoronavirusDomain
A [auth AAA]IPR043611Coronavirus replicase NSP3, C-terminalDomain
A [auth AAA]IPR044864Non-structural protein NSP3, SUD-N (Mac2) domain, betacoronavirusDomain
A [auth AAA]IPR038123Non-structural protein NSP4, C-terminal superfamily, coronavirusHomologous Superfamily
A [auth AAA]IPR042570Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirusHomologous Superfamily
A [auth AAA]IPR047566Coronavirus replicase NSP3, Y domainDomain
A [auth AAA]IPR043178Papain-like protease, thumb domain superfamily, coronavirusHomologous Superfamily
A [auth AAA]IPR043612Non-structural protein NSP4, N-terminal, coronavirusDomain
A [auth AAA]IPR038166Polyprotein cleavage domain PL2pro superfamily, betacoronavirusHomologous Superfamily
A [auth AAA]IPR044353NSP3, second ubiquitin-like (Ubl) domain, coronavirusDomain
A [auth AAA]IPR009003Peptidase S1, PA clanHomologous Superfamily
A [auth AAA]IPR013016Peptidase C16, coronavirusDomain
A [auth AAA]IPR037204Non-structural protein NSP7 superfamily, coronavirusHomologous Superfamily
A [auth AAA]IPR044357NSP3, first ubiquitin-like (Ubl) domain, coronavirusDomain
A [auth AAA]IPR046443NSP1, globular domain, alpha/betacoronavirusDomain
A [auth AAA]IPR043610Non-structural protein 6, coronavirusDomain
A [auth AAA]IPR043477Peptidase C30, domain 3, coronavirusHomologous Superfamily
A [auth AAA]IPR018995RNA synthesis protein NSP10, coronavirusDomain
A [auth AAA]IPR043478Non-structural protein NSP3, SUD-N (Mac2) domain superfamily, betacoronavirusHomologous Superfamily
A [auth AAA]IPR038400Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirusHomologous Superfamily
A [auth AAA]IPR046442NSP1, C-terminal domain, betacoronavirusDomain
A [auth AAA]IPR043615Nonstructural protein 2, N-terminal domain, coronavirusDomain
A [auth AAA]IPR043177Papain-like protease, N-terminal domain superfamily, coronavirusHomologous Superfamily
A [auth AAA]IPR014822Non-structural protein NSP9, coronavirusDomain
A [auth AAA]IPR038030NSP1 globular domain superfamily, betacoronavirusHomologous Superfamily
A [auth AAA]IPR021590NSP1, globular domain, betacoronavirusDomain
A [auth AAA]IPR024375Non-structural protein NSP3, SUD-M domain, betacoronavirusDomain
A [auth AAA]IPR044367Non-structural protein 6, betacoronavirusDomain
A [auth AAA]IPR037230Non-structural protein NSP8 superfamily, coronavirusHomologous Superfamily
A [auth AAA]IPR014828Non-structural protein NSP7, coronavirusDomain
A [auth AAA]IPR032505Non-structural protein NSP4, C-terminal, coronavirusDomain
A [auth AAA]IPR043503Papain-like viral protease, palm and finger domains, coronavirusHomologous Superfamily
A [auth AAA]IPR014829Non-structural protein NSP8, coronavirusDomain
A [auth AAA]IPR036499Non-structural protein NSP9 superfamily, coronavirusHomologous Superfamily
A [auth AAA]IPR002589Macro domainDomain
A [auth AAA]IPR047567Non-structural protein NSP3, group 2-specific marker domain, betacoronavirusDomain
A [auth AAA]IPR044389Non-structural protein 2, SARS-CoV-likeDomain
A [auth AAA]IPR008740Peptidase C30, coronavirusDomain
A [auth AAA]IPR036333RNA synthesis protein NSP10 superfamily, coronavirusHomologous Superfamily
A [auth AAA]IPR047573Non-structural protein 2, middle domain, coronavirusDomain
A [auth AAA]IPR049894Coronavirus NSP3, 3Ecto domainDomain
A [auth AAA]IPR043472Macro domain-likeHomologous Superfamily
A [auth AAA]IPR044371Non-structural protein 3, X-domain-likeDomain
A [auth AAA]IPR032592Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirusDomain
A [auth AAA]IPR043613Non-structural protein 2, C-terminal domain, coronavirusDomain
A [auth AAA]IPR038083Non-structural protein NSP3A domain-like superfamilyHomologous Superfamily
A [auth AAA]IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily