8W4E

Crystal structure of the sigma-1 receptor from Xenopus laevis in the absence of known ligands (C2 form)

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF04622	ERG2 and Sigma1 receptor like protein (ERG2_Sigma1R)	ERG2 and Sigma1 receptor like protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Sigma non-opioid intracellular receptor 1	-	organic hydroxy compound metabolic process steroid metabolic process sterol metabolic process lipid biosynthetic process alcohol metabolic process ergosterol biosynthetic process cellular lipid biosynthetic process small molecule metabolic process ergosterol metabolic process steroid biosynthetic process phytosteroid metabolic process secondary alcohol biosynthetic process small molecule biosynthetic process cellular metabolic process organic hydroxy compound metabolic process steroid metabolic process sterol metabolic process lipid biosynthetic process alcohol metabolic process ergosterol biosynthetic process cellular lipid biosynthetic process small molecule metabolic process ergosterol metabolic process steroid biosynthetic process phytosteroid metabolic process secondary alcohol biosynthetic process small molecule biosynthetic process cellular metabolic process primary metabolic process phytosteroid biosynthetic process secondary alcohol metabolic process biosynthetic process sterol biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process cellular lipid metabolic process metabolic process cellular process lipid metabolic process localization transport macromolecule localization lipid localization lipid transport establishment of localization	membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle vesicle organelle inner membrane nuclear membrane membrane nucleus membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle vesicle organelle inner membrane nuclear membrane membrane nucleus endomembrane system organelle envelope nuclear inner membrane nuclear envelope organelle membrane nuclear outer membrane organelle outer membrane bounding membrane of organelle nuclear outer membrane-endoplasmic reticulum membrane network outer membrane organelle subcompartment endoplasmic reticulum subcompartment endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR006716	ERG2/sigma1 receptor-like	Family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Novel Receptors	Sigma-1 (σ1) receptor complexed with progesterone by co-crstayllization, I432 space group

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.