9AXC

Activated CRAF/MEK heterotetramer from focused refinement of CRAF/MEK/14-3-3 complex


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyProtein kinase-like (PK-like) 8069273 3000066 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyProtein kinase-like (PK-like) 8069273 3000066 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyProtein kinase-like (PK-like) 8042320 3000066 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyProtein kinase-like (PK-like) 8042320 3000066 SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF00069Protein kinase domain (Pkinase)Protein kinase domain- Domain
B, D
PF00069Protein kinase domain (Pkinase)Protein kinase domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
GST26/CRAF chimera
B, D
Dual specificity mitogen-activated protein kinase kinase 1

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, C
PharosP04049
B, D
PharosQ02750