Download MendeleyHuman Tyk2 Pseudokinase Domain Bound to a Kinase Inhibitor
Elkins, J.M., Wang, J., Krojer, T., Savitsky, P., Chalk, R., Daga, N., Salah, E., Berridge, G., Picaud, S., von Delft, F., Bountra, C., Edwards, A., Knapp, S.To be published.
3ZON
Human TYK2 pseudokinase domain bound to a kinase inhibitor
- PDB DOI: https://doi.org/10.2210/pdb3ZON/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Spodoptera frugiperda
- Mutation(s): No
- Deposited: 2013-02-22 Released: 2013-04-10
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.15 Å
- R-Value Free: 0.268
- R-Value Work: 0.214
- R-Value Observed: 0.217
Starting Model: experimental
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This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 | 335 | Homo sapiens | Mutation(s): 0 EC: 2.7.11.1 (PDB Primary Data), 2.7.10.2 (PDB Primary Data) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P29597 (Homo sapiens) Explore P29597 Go to UniProtKB: P29597 | |||||
PHAROS: P29597 GTEx: ENSG00000105397 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P29597 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| IK1 Query on IK1 | B [auth A] | 5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE C12 H11 N3 O2 S PSVUSJKZJQMCSP-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.15 Å
- R-Value Free: 0.268
- R-Value Work: 0.214
- R-Value Observed: 0.217
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 47.81 | α = 90 |
| b = 83.72 | β = 90 |
| c = 91.22 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| MOSFLM | data reduction |
| Aimless | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2013-04-10 Deposition Author(s): Elkins, J.M., Wang, J., Krojer, T., Savitsky, P., Chalk, R., Daga, N., Salah, E., Berridge, G., Picaud, S., von Delft, F., Bountra, C., Edwards, A., Knapp, S.
Revision History (Full details and data files)
- Version 1.0: 2013-04-10
Type: Initial release - Version 1.1: 2018-01-24
Changes: Database references - Version 1.2: 2023-12-20
Changes: Data collection, Database references, Derived calculations, Other, Refinement description
