Download MendeleyCo-crystal structure of the regulatory domain of Toxoplasma gondii PKA with cAMP
El Bakkouri, M., Walker, J.R., Tempel, W., Loppnau, P., Graslund, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Lin, L.To be published.
5J3U
Co-crystal structure of the regulatory domain of Toxoplasma gondii PKA with cAMP
- PDB DOI: https://doi.org/10.2210/pdb5J3U/pdb
- Classification: TRANSFERASE
- Organism(s): Toxoplasma gondii
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2016-03-31 Released: 2016-04-20
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.204
- R-Value Work: 0.170
- R-Value Observed: 0.171
Starting Models: experimental
View more details
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Protein Kinase A | 261 | Toxoplasma gondii | Mutation(s): 0 Gene Names: TGME49_311300, TGVEG_311300 EC: 2.7.11.12 |  | |
UniProt | |||||
Find proteins for A0A0F7V8B2 (Toxoplasma gondii (strain ATCC 50861 / VEG)) Explore A0A0F7V8B2 Go to UniProtKB: A0A0F7V8B2 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | A0A0F7V8B2 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| CMP Query on CMP | B [auth A], C [auth A] | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE C10 H12 N5 O6 P IVOMOUWHDPKRLL-KQYNXXCUSA-N |  | ||
| GOL Query on GOL | D [auth A], E [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.204
- R-Value Work: 0.170
- R-Value Observed: 0.171
- Space Group: P 2 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 36.857 | α = 90 |
| b = 59.414 | β = 90 |
| c = 120.843 | γ = 90 |
| Software Name | Purpose |
|---|---|
| Aimless | data scaling |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| XDS | data reduction |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2016-04-20 Deposition Author(s): El Bakkouri, M., Walker, J.R., Tempel, W., Loppnau, P., Graslund, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Lin, L., Structural Genomics Consortium (SGC)
Revision History (Full details and data files)
- Version 1.0: 2016-04-20
Type: Initial release - Version 1.1: 2023-09-27
Changes: Data collection, Database references, Derived calculations, Refinement description - Version 1.2: 2024-11-13
Changes: Structure summary
