AURKC INCENP complex bound to BRD-7880
Abdul Azeez, K.R., Elkins, J.M.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Aurora kinase C | 274 | Homo sapiens | Mutation(s): 0  Gene Names: AURKC, AIE2, AIK3, AIRK3, ARK3, STK13 EC: 2.7.11.1 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9UQB9 (Homo sapiens) Explore Q9UQB9  Go to UniProtKB:  Q9UQB9 | |||||
PHAROS:  Q9UQB9 GTEx:  ENSG00000105146  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q9UQB9 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 2 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Inner centromere protein | 70 | Homo sapiens | Mutation(s): 0  Gene Names: INCENP | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9NQS7 (Homo sapiens) Explore Q9NQS7  Go to UniProtKB:  Q9NQS7 | |||||
PHAROS:  Q9NQS7 GTEx:  ENSG00000149503  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q9NQS7 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 2 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
VX6 Query on VX6 | C [auth A] | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE C23 H28 N8 O S GCIKSSRWRFVXBI-UHFFFAOYSA-N | |||
SO4 Query on SO4 | D [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |
Modified Residues 2 Unique | |||||
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ID | Chains | Type | Formula | 2D Diagram | Parent |
TPO Query on TPO | A | L-PEPTIDE LINKING | C4 H10 N O6 P | THR | |
SEP Query on SEP | B | L-PEPTIDE LINKING | C3 H8 N O6 P | SER |
Length ( Å ) | Angle ( ˚ ) |
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a = 82.617 | α = 90 |
b = 82.617 | β = 90 |
c = 121 | γ = 120 |
Software Name | Purpose |
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REFMAC | refinement |
XDS | data reduction |
Aimless | data scaling |
PHASER | phasing |